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| Description
| - Expozice k šestivaznému chromu vyvolává různé nežádoucí účinky jako hluboké kožní vředy a alergickou dermatitidu. Díky jeho komplikované chemii mechanismus účinku chromu není zcela objasněn. V této práci jsme zkoumali vliv chromanu draselného (1.5-45 mikroM) na buněčnou motilitu cytoskeletální organizaci, oxidativní stres, mitochondrální aktivitu a aktivaci apoptózy u lidských kožních fibroblastů během 24 hodin. Chroman draselný indukoval časově a koncentračně závislou reorganizaci cytoskeletu, buněčné smrštění a ztrátu motilní aktivity. Tyto změny byly doprovázeny snížením mitochondriálního potenciálu, zvýšením oxidačního stresu a uvolněním cytochromu c. U umírajících buněk byla potvrzena aktivace kaspázy 3. Tato výsledky naznačují, že šestivazný chrom poškozuje cytoskelet a mitochondrie v časných stádiích a změny v těchto cílech aktivují na mitochondriích závislou i nezávislou apoptózu. (cs)
- Exposure to hexavalent chromium causes various adverse effects including deep skin ulcerations and allergic dermatitis. Because of many potential intracellular targets for hexaval are not entirely understood. To investigate the role of the cytoskeleton and mitochondria in this process, primary human dermal fibroplasts were exposed to various concentrations of potassium chromate for 24 h. The followed markers included cell motility, cytoskeletal organization, oxidative stress, mitochondrial activity and activation of the apoptotic cascade. Potassium chromate (1.5-45 mikroM) induced time- and concentration-dependent cell shrinkage, reorganization of cytoskeleton and loss of motile activity in fibroplasts. In some cells this was followed by membrane blebbing. Dynamic changes in cell morphology were accompanied with the loss of mitochondrial membrane potential, increased oxidative stress and release of cytochrome c.
- Exposure to hexavalent chromium causes various adverse effects including deep skin ulcerations and allergic dermatitis. Because of many potential intracellular targets for hexaval are not entirely understood. To investigate the role of the cytoskeleton and mitochondria in this process, primary human dermal fibroplasts were exposed to various concentrations of potassium chromate for 24 h. The followed markers included cell motility, cytoskeletal organization, oxidative stress, mitochondrial activity and activation of the apoptotic cascade. Potassium chromate (1.5-45 mikroM) induced time- and concentration-dependent cell shrinkage, reorganization of cytoskeleton and loss of motile activity in fibroplasts. In some cells this was followed by membrane blebbing. Dynamic changes in cell morphology were accompanied with the loss of mitochondrial membrane potential, increased oxidative stress and release of cytochrome c. (en)
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| Title
| - Hexavalent chromium disrupts the actin cytoskeleton and induces mitochondria-dependent apoptosis in human dermal fibroplasts
- Hexavalent chromium disrupts the actin cytoskeleton and induces mitochondria-dependent apoptosis in human dermal fibroplasts (en)
- Šestivazný chrom poškozuje aktinový cytoskelet a indukuje apoptózu pomocí mitochondriální cesty u lidských kožních fibroblastů (cs)
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| skos:prefLabel
| - Hexavalent chromium disrupts the actin cytoskeleton and induces mitochondria-dependent apoptosis in human dermal fibroplasts
- Hexavalent chromium disrupts the actin cytoskeleton and induces mitochondria-dependent apoptosis in human dermal fibroplasts (en)
- Šestivazný chrom poškozuje aktinový cytoskelet a indukuje apoptózu pomocí mitochondriální cesty u lidských kožních fibroblastů (cs)
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| skos:notation
| - RIV/00216208:11150/05:00003526!RIV06-MSM-11150___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/05:00003526
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Hexavalent chromium; cytoskeleton; mitochondria; apoptosis; fibroblasts (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Cerman, Jaroslav
- Rudolf, Emil
- Červinka, Miroslav
- Schröterová, Ladislava
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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