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| rdf:type
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| Description
| - Porovnávali jsme změny v aktivitě acetylcholinesterázy (AChE) v mozku a motorických ploténkách bránice u potkanů po podání střední smrtící dávky (LD(50)) somanu a tabunu. Používali jsme histochemické stanovení AChE podle Karnovského a Rootse. V kontrolní skupině byla nejvyšší aktivita AChE nalezena ve striatu, amygdale, substantia nigra, colliculi superiores a motorických jádrech hlavových nervů V, X a XII. LD(50) obou neurotoxických látek dramaticky snížila aktivitu AChE jak v mozku, tak v bránici. Po intoxikaci jednou nebo druhou látkou aktivita ve výše uvedených jádrech byla charakterizována jako nízká nebo ohniskově střední. V některých jiných strukturách mozku byla aktivita velmi nízká. Nalezli jsme minimální rozdíly v histochemickém obraze intoxikace somanem nebo tabunem, kromě striata a colliculi superiores, které jevily silnější inhibici tabunem (cs)
- The aim of this study was to compare changes in activity of acetylcholinesterase (AChE) in the brain and motor endplates of rat after administration of soman and tabun. We took brain and diaphragm from laboratory rats administered a median lethal dose (LD(50)) of soman or tabun. Enzyme activity of AChE was studied in selected structures of brain and in motor endplates in the diaphragm. Histochemical detection of AChE by Karnovski and Roots with simultaneous histochemical detection of alkaline phosphatase in case of brain sections was used. The highest activity of AChE in the control group was found in the striatum, amygdaloid nuclei, substantia nigra, superior colliculi, and motor nuclei of cranial nerves V, X a XII. LD(50) of both nerve agents dramatically decreased the activity of AChE in the structures studied--both brain and diaphragm. After intoxication by either agent, activity in above mentioned nuclei was characterized as low or focally moderate.
- The aim of this study was to compare changes in activity of acetylcholinesterase (AChE) in the brain and motor endplates of rat after administration of soman and tabun. We took brain and diaphragm from laboratory rats administered a median lethal dose (LD(50)) of soman or tabun. Enzyme activity of AChE was studied in selected structures of brain and in motor endplates in the diaphragm. Histochemical detection of AChE by Karnovski and Roots with simultaneous histochemical detection of alkaline phosphatase in case of brain sections was used. The highest activity of AChE in the control group was found in the striatum, amygdaloid nuclei, substantia nigra, superior colliculi, and motor nuclei of cranial nerves V, X a XII. LD(50) of both nerve agents dramatically decreased the activity of AChE in the structures studied--both brain and diaphragm. After intoxication by either agent, activity in above mentioned nuclei was characterized as low or focally moderate. (en)
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| Title
| - Comparison of changes in AChE activity in the brain of the laboratory rat after soman and tabun intoxication
- Comparison of changes in AChE activity in the brain of the laboratory rat after soman and tabun intoxication (en)
- Porovnání změn aktivity acetylcholinesterázy v mozku laboratorního potkana po intoxikaci somanem a tabunem. (cs)
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| skos:prefLabel
| - Comparison of changes in AChE activity in the brain of the laboratory rat after soman and tabun intoxication
- Comparison of changes in AChE activity in the brain of the laboratory rat after soman and tabun intoxication (en)
- Porovnání změn aktivity acetylcholinesterázy v mozku laboratorního potkana po intoxikaci somanem a tabunem. (cs)
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| skos:notation
| - RIV/00216208:11150/04:00004642!RIV08-MSM-11150___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/04:00004642
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Comparison; changes; activity; brain; laboratory; after; soman; tabun; intoxication (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hájek, Petr
- Krs, Otakar
- Slížová, Dáša
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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