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| Description
| - The aim of the present study was to evaluate CDDO activity in EOC cell lines in vitro. Conclusions. Although differences were observed in PPARgama expression in EOC cell lines, CDDO had similar growth-inhibitory activity in all cell lines examined, indicating that the antitumor activity of CDDO in vitro is mediated by a mechanism independent of PPARgama. The activity of CDDO in platinum-resistant cell lines is encouraging with respect to the potential clinical use of the drug.
- The aim of the present study was to evaluate CDDO activity in EOC cell lines in vitro. Conclusions. Although differences were observed in PPARgama expression in EOC cell lines, CDDO had similar growth-inhibitory activity in all cell lines examined, indicating that the antitumor activity of CDDO in vitro is mediated by a mechanism independent of PPARgama. The activity of CDDO in platinum-resistant cell lines is encouraging with respect to the potential clinical use of the drug. (en)
- Cíle:epiteliální ovariální karcinom (EOC) je stále vedoucí příčinou smrti ve skupině gynekologických malignit. 2-cyano-3,12-dioxoolean-1,9-dien-28-ová kyselina (CDDO) je nový syntetický triterpenoid, který je ligandem peroxizómy proliferátory-aktivovaného receptoru gama (PPARgama). Cílem této studie bylo zhodnotit aktivitu CDDO na EOC liniích in vitro. Metody: exprese PPARgama byla sledována pomocí real-time RT-PCR u 8 linií (2774, SKOV3, CAOV3, OVCAR3, MNP-1, HEY, 2008 a 2008.C13) a růstově inhibiční aktivita byla stanovována pomocí MTT testu. Výsledky: CDDO vykazovala stejnou aktivitu u různých EOC liniích, a to nezávisle na citlivosti na cisplatinu; 50% inhibiční koncentrace byly v rozmezí 1-4 µM. Kombinace CDDO s cisplatinou či paclitaxelem ukázaly slabý antagonismus. Závěry: mechanismus cytostatické aktivity CDDO na EOC liniích je nezávislý na expresi PPARgama. Aktivita CCDO se jeví jako slibná pro další testování. (cs)
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| Title
| - Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-
- Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor- (en)
- Inhibiční efekt nově syntetizovaného triterpenoidu, , 2-cyano-3,12-dioxoolean-1,9dien-28-ové kyseliny, na růst linií ovariálního karcinomu nezávislý na PPAR- (cs)
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| skos:prefLabel
| - Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-
- Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor- (en)
- Inhibiční efekt nově syntetizovaného triterpenoidu, , 2-cyano-3,12-dioxoolean-1,9dien-28-ové kyseliny, na růst linií ovariálního karcinomu nezávislý na PPAR- (cs)
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| skos:notation
| - RIV/00216208:11150/04:00004565!RIV08-MSM-11150___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/04:00004565
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Growth-inhibitory; effect; novel; synthetic; triterpenoid; 2-cyano-3; 12-dioxoolean-1; 9dien-28-oic; ovarian; carcinoma; lines; dependent; peroxisome; proliferator-activated; receptor- (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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