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| Description
| - We studied the extent to which hormonally-induced mitochondrial glycerophosphate dehydrogenase (mGPDH) activity contributes to the supply of reducing equivalents to the mitochondrial respiratory chain in the rat liver. The activity of glycerophosphate oxidase was compared with those of NADH oxidase and/or succinate oxidase. It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturaton of the respiratory chain as Complex II. Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production. As a result of hormonal treatment, a 3-fold increase in glycerophosphate-dependent hydrogen peroxide production by liver mitochondria was detected by polarographic and luminometric measurements.
- We studied the extent to which hormonally-induced mitochondrial glycerophosphate dehydrogenase (mGPDH) activity contributes to the supply of reducing equivalents to the mitochondrial respiratory chain in the rat liver. The activity of glycerophosphate oxidase was compared with those of NADH oxidase and/or succinate oxidase. It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturaton of the respiratory chain as Complex II. Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production. As a result of hormonal treatment, a 3-fold increase in glycerophosphate-dependent hydrogen peroxide production by liver mitochondria was detected by polarographic and luminometric measurements. (en)
- Byl studován rozsah, jakým přispívá hormonálně indukovaná aktivita mitochondriální glycerofosfátdehydrogenázy (mGDPH) dodání redukovaných ekvivalentů respiračnímu řetězci mitochondrií v játrech potkana. Byla porovnána aktivita glycerofosfátoxidázy s aktivitou NADH-oxidázy a sukcinátoxidázy. Bylo prokázáno, že trijódtyroninem aktivovaná mGDPH přispívá saturaci respiračního řetězce téměř stejnou kapacitou jako komplex II. Vzestup aktivity mGDPH indukovaný podáním trijódtyroninu koreloval také se vzestupem kapacity pro glycerofosfát-dependentní tvorbu peroxidu vodíku. Pomocí polarografického a luminometrického měření byl prokázán trojnásobný vzestup glycerofosfát-dependentní tvorby peroxidu vodíku v jaterních mitochondriích v důsledku hormonální stimulace. (cs)
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| Title
| - Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria
- Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria (en)
- Glycerofosfát-dependentní tvorba peroxidu vodíku v jaterních mitochondriích potkana (cs)
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| skos:prefLabel
| - Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria
- Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria (en)
- Glycerofosfát-dependentní tvorba peroxidu vodíku v jaterních mitochondriích potkana (cs)
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| skos:notation
| - RIV/00216208:11150/04:00002117!RIV/2005/MSM/111505/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA303/03/0799), P(OC 918.50), Z(AV0Z5011922), Z(MSM 111100003), Z(MSM 111300003), Z(MSM 111500003)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/04:00002117
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - rat liver mitochondria; mitochondrial glycerophosphate dehydrogenase; tiiodothyronine; hydrogen peroxide (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Červinková, Zuzana
- Bolehovská, Radka
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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