About: Interaction of Francisella tularensis Live Vaccine Strain with Eukaryotic Cells

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About: Interaction of Francisella tularensis Live Vaccine Strain with Eukaryotic Cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In vitro a ex vivo myší modely infekce s živým vakcinačním kmenem Francisella tularensis LVS byly použity pro studium časných fází interakcí bakterií a hostitelských buněk. Pomocí elektronové mikroskopie bylo zjištěno, že F. tularensis LVS je schopna uniknout z fagozomů. Tato schopnost je ovlivněna genetickým pozadím a imunním stavem hostitele. Subcelulární frakcionace infikovaných hostitelských buněk potvrdila únik tularemických mikrobů z fagozomů a jejich asociací s proteiny mitochondrií a endoplazmatického retikula. Fenotypová analýza a analýza profilu cytokínů infikovaných J774 buněčné linie dokumentovala modulaci exprese CD16/32, CD54 a CD86 a produkci citokínů TNF alfa, IL-6, IL-10 a IL-12. (cs) The in vitro and ex vivo murine models of infection with live vaccine strain of Francisella tularensis LVS were used for the study of early phases of bacteria-host cell interactions. The electron microscopic study revealed the ability of F. tularensis LVS to escape from the phagosomes. This ability is influenced by genetic background and immune status of the host. Subcellular fractination of infected host cells confirmed the escape of tularemia microbes from phagosomes and their association with mitochondrial and endoplasmic reticulum proteins. Phenotypic analysis and analysis of cytokine profiles of infected J774 cell line documented the modulation of CD16/32, CD54, and CD86 expression and TNF-alfa, IL-6, IL-10, and IL-12 cytokine production. The in vitro and ex vivo murine models of infection with live vaccine strain of Francisella tularensis LVS were used for the study of early phases of bacteria-host cell interactions. The electron microscopic study revealed the ability of F. tularensis LVS to escape from the phagosomes. This ability is influenced by genetic background and immune status of the host. Subcellular fractination of infected host cells confirmed the escape of tularemia microbes from phagosomes and their association with mitochondrial and endoplasmic reticulum proteins. Phenotypic analysis and analysis of cytokine profiles of infected J774 cell line documented the modulation of CD16/32, CD54, and CD86 expression and TNF-alfa, IL-6, IL-10, and IL-12 cytokine production. (en)
Title	Interaction of Francisella tularensis Live Vaccine Strain with Eukaryotic Cells Interaction of Francisella tularensis Live Vaccine Strain with Eukaryotic Cells (en) Interakce Francisella tularensis Live Vaccine Strain s eukaryotickými buňkami (cs)
skos:prefLabel	Interaction of Francisella tularensis Live Vaccine Strain with Eukaryotic Cells Interaction of Francisella tularensis Live Vaccine Strain with Eukaryotic Cells (en) Interakce Francisella tularensis Live Vaccine Strain s eukaryotickými buňkami (cs)
skos:notation	RIV/00216208:11150/04:00002075!RIV/2005/MSM/111505/N
http://linked.open.../vavai/riv/strany	417;421
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LN00A033)
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Andělová, Hana Novosadová, Martina Novosad, Jakub Holická, Monika Stulík, Jiří
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	568552
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/04:00002075
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Francisella tularensis; phagosomes; cytokines production (en)
http://linked.open.../riv/klicoveSlovo	cytokines production phagosomes Francisella tularensis
http://linked.open...ontrolniKodProRIV	[92AB0E72792C]
http://linked.open...i/riv/mistoVydani	Bologna
http://linked.open...i/riv/nazevZdroje	Immunology 2004
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	The proteome center for the study of intracellular parasitism of microbes
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Holická, Monika Novosad, Jakub Stulík, Jiří Andělová, Hana Loudová, Martina
number of pages	5 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Monduzzi Editore
https://schema.org/isbn	88-7587-069-1
http://localhost/t...ganizacniJednotka	11150

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