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  • The role of intracellular free zinc and its chelation by TPEN was studied in Bowes human melanoma cells. The content of free Zn pools was determined by fluorescent probe Zinquin. Depletion of zinc triggered apoptosis confirmed by cell blebbing, changes in mitochondrial tgransmemb rane potential and GSH levels, caspase-3 activ ation and nuclear fragmentation. Apoptosis was only partially prevented by cyclosporin A or N-acetylcystein, suggesting various independent but likely interrelated mechanisms participating in this process.
  • The role of intracellular free zinc and its chelation by TPEN was studied in Bowes human melanoma cells. The content of free Zn pools was determined by fluorescent probe Zinquin. Depletion of zinc triggered apoptosis confirmed by cell blebbing, changes in mitochondrial tgransmemb rane potential and GSH levels, caspase-3 activ ation and nuclear fragmentation. Apoptosis was only partially prevented by cyclosporin A or N-acetylcystein, suggesting various independent but likely interrelated mechanisms participating in this process. (en)
  • Práce zkoumá úlohu intracelulárního volného zinku a jeho chelace pomocí TPEN u lidských melanomových buněk Bowes. Obsah zinku byl měřen pomocí fluorescenční proby Zinquin. Deplece zinku vyvolala apoptózu potvrzenou přítomností blebování, změnami v mitochondriálním potenciálu a hladin GSH, aktivací kaspázy-3 a fragmentací jádra. Apoptóza byla částečně potlačena cyklosporinem A či N-acetylcysteinem. (cs)
Title
  • Depletion of endogenous zinc stores induces oxidative stress and cell death in human melanoma cells
  • Depletion of endogenous zinc stores induces oxidative stress and cell death in human melanoma cells (en)
  • Vyprázdnění endogenních zásobáren zinku indukuje oxidativní stres a buněčnou smrt u lidských melanomových buněk (cs)
skos:prefLabel
  • Depletion of endogenous zinc stores induces oxidative stress and cell death in human melanoma cells
  • Depletion of endogenous zinc stores induces oxidative stress and cell death in human melanoma cells (en)
  • Vyprázdnění endogenních zásobáren zinku indukuje oxidativní stres a buněčnou smrt u lidských melanomových buněk (cs)
skos:notation
  • RIV/00216208:11150/04:00002050!RIV/2005/MSM/111505/N
http://linked.open.../vavai/riv/strany
  • 91;96
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 111500001)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 559745
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/04:00002050
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • human melanoma cells; labile zinc; cell death; mitochondria; oxidative stress (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [3ABFF77356A9]
http://linked.open...i/riv/nazevZdroje
  • Acta Medica (Hradec Králové)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 47
http://linked.open...iv/tvurceVysledku
  • Rudolf, Emil
  • Červinka, Miroslav
http://linked.open...n/vavai/riv/zamer
issn
  • 1211-4286
number of pages
http://localhost/t...ganizacniJednotka
  • 11150
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