About: Protein metabolism in guanethidine-treated rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the present study was to evaluate using male rats the effect of short-term adrenergic blockade on the rate of whole-body protein turnover and leucine oxidation, and on protein synthesis in specific tissues. Adrenergic blockade was induced by guanethidine (100 mg/b.w. subcutaneously). There was insignificant effect of guanethidine on whole-body proteolysis, protein synthesis, and leucine clearance. However, protein balance was more negative due to the higher difference between protein synthesis and proteolysis in guanethidine treated animals than in controls. In guanethidine treated rats, protein synthesis was higher in gastrocnemius muscle and in the kidneys and lower in liver and spleen. Changes in small intestine and colon were insignificant. It is concluded that adrenergic blockade induced by guanethidine is associated with significant changes in protein metabolism, leucine oxidation and amino acid concentrations in several tissues. The aim of the present study was to evaluate using male rats the effect of short-term adrenergic blockade on the rate of whole-body protein turnover and leucine oxidation, and on protein synthesis in specific tissues. Adrenergic blockade was induced by guanethidine (100 mg/b.w. subcutaneously). There was insignificant effect of guanethidine on whole-body proteolysis, protein synthesis, and leucine clearance. However, protein balance was more negative due to the higher difference between protein synthesis and proteolysis in guanethidine treated animals than in controls. In guanethidine treated rats, protein synthesis was higher in gastrocnemius muscle and in the kidneys and lower in liver and spleen. Changes in small intestine and colon were insignificant. It is concluded that adrenergic blockade induced by guanethidine is associated with significant changes in protein metabolism, leucine oxidation and amino acid concentrations in several tissues. (en)
Title	Protein metabolism in guanethidine-treated rats Protein metabolism in guanethidine-treated rats (en)
skos:prefLabel	Protein metabolism in guanethidine-treated rats Protein metabolism in guanethidine-treated rats (en)
skos:notation	RIV/00216208:11150/04:00002022!RIV10-GA0-11150___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA303/03/1512)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Holeček, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	582863
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/04:00002022
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adrenergic blockade; catecholamines; leucine; sympathetic system (en)
http://linked.open.../riv/klicoveSlovo	catecholamines sympathetic system leucine adrenergic blockade
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A7D54A15F893]
http://linked.open...i/riv/nazevZdroje	International Journal of Experimental Pathology
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	The possibilities to affect the negative protein balance in severe illness - the effect of proteasome inhibitors
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Holeček, Milan
http://linked.open...ain/vavai/riv/wos	000223997200003
issn	0959-9673
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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