About: The Functional Association Between COMT Gene Polymorphism and Visual Attention in Schizophrenic Psychosis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Katechol-O-methyl transferáza (COMT) je postsynaptický enzym, který inaktivuje uvolněný dopamin a jiné katacholaminy. Činnost COMT je polymorfní vzhledem k G k A přechodu na kodonu 158 na chromozomu 22q 11, která se přeměňuje na valin-methionin změnu v peptidové sekvenci. COMT s Val alelou rychleji inaktivuje uvolňující se dopamin oproti Met alele. V naší studii jsme zjistili ve skupině 44 pacientů se schizofrenní poruchou, že polymorfismus COMT ovlivňuje výsledek vizuální pozornost, měřený pomocí CPT II testu. ValVal homozygoty mají nejhorší výsledek v komisních chybách a reakční době. Toto zjištění potvrzuje roli polymorfismu COMT a kognitivního deficitu u schizofrenie. (cs) Catechol-O-methyl transferase (COMT) is a postsynaptic enzyme that inactivates released dopamine and other catacholamines. The COMT activity is polymorphic due to the G to A transition at codon 158 on chromosome 22q 11 which translates into valine-to-methionine change in the peptide sequence. COMT with Val allele more rapidly inactivates released dopamine comparing to Met allele. In our study we found in the group of 44 patients with schizophrenic disorder that COMT polymorphism influences the outcome in visual attention measured by the CPT II test. ValVal homozygotes have worst outcome in commission errors and reaction time. This finding confirms the role of COMT polymorphism and cognitive deficit in schizophrenia. Catechol-O-methyl transferase (COMT) is a postsynaptic enzyme that inactivates released dopamine and other catacholamines. The COMT activity is polymorphic due to the G to A transition at codon 158 on chromosome 22q 11 which translates into valine-to-methionine change in the peptide sequence. COMT with Val allele more rapidly inactivates released dopamine comparing to Met allele. In our study we found in the group of 44 patients with schizophrenic disorder that COMT polymorphism influences the outcome in visual attention measured by the CPT II test. ValVal homozygotes have worst outcome in commission errors and reaction time. This finding confirms the role of COMT polymorphism and cognitive deficit in schizophrenia. (en)
Title	The Functional Association Between COMT Gene Polymorphism and Visual Attention in Schizophrenic Psychosis The Functional Association Between COMT Gene Polymorphism and Visual Attention in Schizophrenic Psychosis (en) Funkční spojitost mezi genovým polymorfismem COMB a vizuální pozorností (cs)
skos:prefLabel	The Functional Association Between COMT Gene Polymorphism and Visual Attention in Schizophrenic Psychosis The Functional Association Between COMT Gene Polymorphism and Visual Attention in Schizophrenic Psychosis (en) Funkční spojitost mezi genovým polymorfismem COMB a vizuální pozorností (cs)
skos:notation	RIV/00216208:11150/03:00004423!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany	14;17
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(LN00B122), S
http://linked.open...iv/cisloPeriodika	Suppl. 3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Beránek, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	607798
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/03:00004423
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Functional; Association; Between; Polymorphism; Visual; Attention; Schizophrenic; Psychosis (en)
http://linked.open.../riv/klicoveSlovo	Visual Between Attention Functional Schizophrenic Association Polymorphism Psychosis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[5B17662B276B]
http://linked.open...i/riv/nazevZdroje	Psychiatrie
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuropsychiatric Research Center
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Beránek, Martin
issn	1211-7579
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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