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| Description
| - Aspirační cytologie tenkou jehlou (FNAC) štítné žlázy je zavedenou metodou, které je však omezeně použitelná v diagnostice folikulárních a onkocytických nádorů a při odlišení atypických jader u koloidní strumy spojené s regresivními změnami a cystickým papilárním karcinomem. Cílem naší studie bylo ohodnotit dipeptydil peptidázu IV (DPP IV) jako marker malignity u FNAC. Testovali jsme 254 vzorků štítné žlázy (intraoperativní imprintové roztěry) na DPP IV. Citlivost byla 71%, specifita 95% a diagnostická přesnost 93% s prahem 50% pozitivních buněk. Podle našeho názoru je to největší histologicky ověřená studie publikovaná v literatuře. Navrhujeme, aby hodnocení DPP IV bylo použito jako přidružený diagnostický marker malignity u vzorků štítné žlázy potenciálně pozitivních na papilární karcinom. Na druhé straně diagnostická hodnota tohoto markeru u folikulárních lézí je velmi omezená. (cs)
- Fine needle aspiration cytology (FNAC) of the thyroid gland is a well-established method. However, it has inherent limitations, especially in the diagnosis of follicular and oncocytic tumours and in distinguishing between nuclear atypia in colloid goitre with regressive changes and cystic papillary carcinoma. The aim of our study was to evaluate dipeptidyl peptidase IV (DPP IV) as a marker of malignancy in FNAC. We tested 254 thyroid specimens (intraoperative imprint smears) for DPP IV. The sensitivity was 71%, the specificity was 96%, and the diagnostic accuracy was 93%, respectively, with a threshold of 50% of positive cells. To the best of our knowledge it is the largest histologically confirmed study reported in the literature. We suggest the assessment of DPP IV as an adjunct diagnostic marker of malignancy in thyroid specimens suspicious of papillary carcinoma. However, the value of the marker in follicular lesions is very limited.
- Fine needle aspiration cytology (FNAC) of the thyroid gland is a well-established method. However, it has inherent limitations, especially in the diagnosis of follicular and oncocytic tumours and in distinguishing between nuclear atypia in colloid goitre with regressive changes and cystic papillary carcinoma. The aim of our study was to evaluate dipeptidyl peptidase IV (DPP IV) as a marker of malignancy in FNAC. We tested 254 thyroid specimens (intraoperative imprint smears) for DPP IV. The sensitivity was 71%, the specificity was 96%, and the diagnostic accuracy was 93%, respectively, with a threshold of 50% of positive cells. To the best of our knowledge it is the largest histologically confirmed study reported in the literature. We suggest the assessment of DPP IV as an adjunct diagnostic marker of malignancy in thyroid specimens suspicious of papillary carcinoma. However, the value of the marker in follicular lesions is very limited. (en)
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| Title
| - Dipeptidyl peptidase IV expression in thyroid cytology: retrospective histologically confirmed study
- Dipeptidyl peptidase IV expression in thyroid cytology: retrospective histologically confirmed study (en)
- Exprese dipeptidyl peptidázy IV v cytologii štítné žlázy: retrospektivní histologicky potvrzená studie (cs)
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| skos:prefLabel
| - Dipeptidyl peptidase IV expression in thyroid cytology: retrospective histologically confirmed study
- Dipeptidyl peptidase IV expression in thyroid cytology: retrospective histologically confirmed study (en)
- Exprese dipeptidyl peptidázy IV v cytologii štítné žlázy: retrospektivní histologicky potvrzená studie (cs)
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| skos:notation
| - RIV/00216208:11150/03:00004312!RIV08-MSM-11150___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/03:00004312
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Dipeptidyl; peptidase; expression; thyroid; cytology; retrospective; histologically; confirmed; study (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Ryška, Aleš
- Kholová, Ivana
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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