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| rdf:type
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| Description
| - The potential toxic effects of repeated administration of the SIH, partly dissolved in 10% Cremophor solution, on various biochemical, haematological and cardiovascular parameters, and on morphology of selected tissues were investigated in rabbits. SIH did not induced marked signs of toxicity. Only a few and mild changes in some biochemical and haematological parameters were found, but most of them were noted also in control saline and Cremophor groups. The morphological changes in the kidney were only mild. Also the cardiac function was not affected markedly. Therefore, the obtained results can be considered to be promising from the standpoint of possible clinical use of the SIH.
- The potential toxic effects of repeated administration of the SIH, partly dissolved in 10% Cremophor solution, on various biochemical, haematological and cardiovascular parameters, and on morphology of selected tissues were investigated in rabbits. SIH did not induced marked signs of toxicity. Only a few and mild changes in some biochemical and haematological parameters were found, but most of them were noted also in control saline and Cremophor groups. The morphological changes in the kidney were only mild. Also the cardiac function was not affected markedly. Therefore, the obtained results can be considered to be promising from the standpoint of possible clinical use of the SIH. (en)
- Byl studován potenciální toxický efekt SIH, částečně rozpuštěného v roztoku 10% Cremophoru, při opakovaném podání králíkům z hlediska biochemických, hematologických a kardiovaskulárních ukazatelů a z hlediska morfologického hodnocení vybraných tkáňových vzorků. SIH nevyvolal žádné zřetelné známky toxicity. Byly nalezeny jen ojedinělé mírné změny v některých biochemických a hematologických parametrech, které se však vyskytly i ve skupině kontrol s fyziologickým roztokem a s Cremophorem. Morfologické změny v ledvině byly také jen mírného stupně. Ani srdeční funkce nebyla zřetelně ovlivněna. Získané výsledky mohou být proto považovány za slibné z hlediska případného využití SIHu pro klinické účely. (cs)
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| Title
| - Studie potencioálního toxického efektu po 10-ti týdenním podávání nového chelatoru železa salicylaldehyd isonicotinoyl hydrazonu (SIH) u králíků (cs)
- A study of potential toxic effects after repeated 10-week administration of a new iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits
- A study of potential toxic effects after repeated 10-week administration of a new iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits (en)
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| skos:prefLabel
| - Studie potencioálního toxického efektu po 10-ti týdenním podávání nového chelatoru železa salicylaldehyd isonicotinoyl hydrazonu (SIH) u králíků (cs)
- A study of potential toxic effects after repeated 10-week administration of a new iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits
- A study of potential toxic effects after repeated 10-week administration of a new iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits (en)
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| skos:notation
| - RIV/00216208:11150/03:00002106!RIV/2005/MSM/111505/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA305/03/1511), V, Z(MSM 111600002)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/03:00002106
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - salicylaldehyde isonicotinoyl hydrazone (SIH); iron chelator; rabbit; biochemistry; haematology; cardiovascular; histology (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Acta Medica (Hradec Králové)
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Adamcová, Michaela
- Geršl, Vladimír
- Mazurová, Yvona
- Kaplanová, Jana
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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