About: The synthesis and production of rage by monocytes during endometriosis: connection with reproductive function of patients

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About: The synthesis and production of rage by monocytes during endometriosis: connection with reproductive function of patients Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Celju raboty bylo ustanovit osobennosti syvorotočnogo soderžanija RAGE i sinteza ego monocitami pri endometrioze v zavisimosti ot stadii rasprostranennosti zabolevanija i sostojanija reproduktivnoj funkcii pacientok dlja utočnenija immunnych mechanizmov razvitija endometrioza i svjazannogo s nim besplodija. Bylo provedeno obsledovanie 80 ženščin s naružnym genitalnym endometriozom i 16 zdorovych fertilnych ženščin (kontrolnaja gruppa). Syvorotočnoe soderžanie RAGE opredeljalos metodom IFA, uroven ekspressii mRNK RAGE v populjacii CD14+ monocitov ocenivali metodom PCR v režime realnogo vremeni. Bylo vyjavleno povyšenie syvorotočnogo soderžanija RAGE v obščej gruppe ženščin s endometriozom, kotoroe korrelirovalo so stadiej endometrioza i s naličiem u pacientok besplodija. Ekspressija mRNK RAGE monocitami takže byla povyšena v obščej gruppe ženščin s endometriozom i u pacientok s endometriozom i besplodiem. Uspech chirurgičeskogo lečenija besplodija i EKO u pacientok s endometriozom byl associirovan s iznačalno nizkim syvorotočnym soderžaniem RAGE. The aim of the work was to establish the character of RAGE serum content and its synthesis by monocytes during endometriosis in dependence on disease degree and reproductive function of patients for elucidation of the immune mechanisms of endometriosis and endometriosisassociated infertility development. 80 women with external genital endometriosis and 16 healthy fertile women (control group) were recruited into the study. Serum level of RAGE was assessed by ELISA, RAGE mRNA expression in population of CD14+ monocytes was estimated by real time PCR. It was established that the serum level of RAGE was increased in general group of women with endometriosis; this increase was associated with the stage of endometriosis and infertility state. mRNA RAGE expression by monocytes was also increased in women with endometriosis and in women with endometriosis accompanied by infertility. Success of the surgical treatment of infertility and IVF in patients with endometriosis was associated with initially low level of serum content of RAGE. (en)
Title	The synthesis and production of rage by monocytes during endometriosis: connection with reproductive function of patients (en) Sintez i produkcija rage monocitami pri endometrioze: svjaz s sostojaniem reproduktivnoj funkcii pacientok
skos:prefLabel	The synthesis and production of rage by monocytes during endometriosis: connection with reproductive function of patients (en) Sintez i produkcija rage monocitami pri endometrioze: svjaz s sostojaniem reproduktivnoj funkcii pacientok
skos:notation	RIV/00216208:11140/14:10286570!RIV15-MSM-11140___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Ulčová-Gallová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	45101
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/14:10286570
http://linked.open...riv/jazykVysledku	rus - ruština
http://linked.open.../riv/klicovaSlova	endometriosis; monocytes; RAGE (en)
http://linked.open.../riv/klicoveSlovo	RAGE endometriosis monocytes
http://linked.open...odStatuVydavatele	RU - Ruská federace
http://linked.open...ontrolniKodProRIV	[F15D15786EDC]
http://linked.open...i/riv/nazevZdroje	Possijskij immunologičeskij žurnal
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Ulčová-Gallová, Zdeňka Antsiferova, Yu.S. Krasilnikova, A. K. Malyshkina, A. I. Romanova, S. V. Sotnikova, N.Yu.
issn	1028-7221
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11140

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