About: Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin

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About: Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/gcc.22195/pdf
Description	Polymorphous low-grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low-grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants of one spectrum, as they appear to have significant overlap, but also clinicopathologic differencese. As many salivary carcinomas harbor recurrent translocations, paired-end RNA sequencing and FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs and two PlGAs. Validated rearrangements were then screened by fluorescence in situ hybridization (FISH) in 60 case. Histologic classification was performed without knowledge of fuion status and included: 21 CAMSG, 18 classic PlGA, and 21 with %22mixed/indeterminate%22 features. Polymorphous low-grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low-grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants of one spectrum, as they appear to have significant overlap, but also clinicopathologic differencese. As many salivary carcinomas harbor recurrent translocations, paired-end RNA sequencing and FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs and two PlGAs. Validated rearrangements were then screened by fluorescence in situ hybridization (FISH) in 60 case. Histologic classification was performed without knowledge of fuion status and included: 21 CAMSG, 18 classic PlGA, and 21 with %22mixed/indeterminate%22 features. (en)
Title	Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin (en)
skos:prefLabel	Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin (en)
skos:notation	RIV/00216208:11140/14:10281769!RIV15-MSM-11140___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Skálová, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	33108
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/14:10281769
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Origin; Gland; Salivary; Adenocarcinoma; Cribriform; Fusions; Variant; Rearrangements; Gene; PRKD; Novel (en)
http://linked.open.../riv/klicoveSlovo	Variant Gene Rearrangements Adenocarcinoma Origin Salivary Novel Cribriform Fusions PRKD Gland
http://linked.open...odStatuVydavatele	HU - Maďarsko
http://linked.open...ontrolniKodProRIV	[BC810ACEBC28]
http://linked.open...i/riv/nazevZdroje	Genes Chromosomes and Cancer [online]
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	22 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Skálová, Alena Perez-Ordonez, Bayardo Weinreb, Ilan Zhang, Lei Assaad, Adel Boutros, Paul C. Chiosea, Simion I Clarke, Blaise A How, Christine Liu, Fei-Fei Seethala, Raja R Thompson, Lester DR Waggott, Daryl Antonescu, Cristina R Chen, Chun-Liang Gilbert, Ralph Goldstein, David P Hornick, Jason L Irish, Jonathan C Sung, Yun-Shao Tirunagari, Laxmi MS ud Din, Nasir
http://linked.open...ain/vavai/riv/wos	000342157900005
issn	1098-2264
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/gcc.22195
http://localhost/t...ganizacniJednotka	11140

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