About: Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels

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About: Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We demonstrated dopamine, noradrenaline and adrenaline in rat aorta and superior mesenteric arteries by radioimmunoassay. Chemical sympathectomy did not affect tissue dopamine levels. Isolated endothelial cells were able to synthesise and release dopamine upon cAMP stimulation. Endothelial and smooth muscle cells expressed catecholaminergic traits (RT-PCR, WB). Exposure of endothelial cells to hypoxia (1% O2) increased tyrosine hydroxylase mRNA. Hypoxic vasodilatation was abrogated by receptor D1-antagonist. In conclusion, endothelial cells and cells of the underlying vascular wall synthesize and release dopamine in an oxygen-regulated manner. We demonstrated dopamine, noradrenaline and adrenaline in rat aorta and superior mesenteric arteries by radioimmunoassay. Chemical sympathectomy did not affect tissue dopamine levels. Isolated endothelial cells were able to synthesise and release dopamine upon cAMP stimulation. Endothelial and smooth muscle cells expressed catecholaminergic traits (RT-PCR, WB). Exposure of endothelial cells to hypoxia (1% O2) increased tyrosine hydroxylase mRNA. Hypoxic vasodilatation was abrogated by receptor D1-antagonist. In conclusion, endothelial cells and cells of the underlying vascular wall synthesize and release dopamine in an oxygen-regulated manner. (en)
Title	Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels (en)
skos:prefLabel	Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels (en)
skos:notation	RIV/00216208:11140/14:10196137!RIV15-MSM-11140___
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM0021620819)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Slavíková, Jana Kuncová, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	22617
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/14:10196137
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Vasodilatation; Hypoxia; Dopamine (en)
http://linked.open.../riv/klicoveSlovo	Hypoxia Vasodilatation Dopamine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[5B6A6BB2B79F]
http://linked.open...i/riv/nazevZdroje	Journal of Physiology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	592
http://linked.open...iv/tvurceVysledku	Kuncová, Jitka Slavíková, Jana Kummer, Wolfgang Pfeil, Uwe Brüggmann, Doerthe Henrich, Michael Mewe, Marco Middendorff, Ralf Paddenberg, Renate Rafiq, Amir Schlutter, Klaus-Dieter Weigand, Markus A.
http://linked.open...ain/vavai/riv/wos	000334114100007
http://linked.open...n/vavai/riv/zamer	Náhrada a podpora funkce některých životně důležitých orgánů
issn	0022-3751
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1113/jphysiol.2013.262626
http://localhost/t...ganizacniJednotka	11140

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