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  • Degenerative aortic stenosis has become a common and dangerous disease in recent decades. This disease leads to the mineralization of aortic valves, their gradual thickening and loss of functionality. We studied the detailed assessment of the proportion and composition of inorganic and organic components in the ossified aortic valve, using a set of analytical methods applied in science: polarized light microscopy, scanning electron microscopy, X-ray fluorescence, X-ray diffraction, gas chromatography/mass spectrometry and liquid chromatography-tandem mass spectrometry. The sample valves showed the occurrence of phosphorus and calcium in the form of phosphate and calcium carbonate, hydroxyapatite, fluorapatite and hydroxy-fluorapatite, with varying content of inorganic components from 65 to 90 wt%, and with phased development of degenerative disability. The outer layers of the plaque contained an organic component with peptide bonds, fatty acids, proteins and cholesterol. The results show a correlation between the formation of fluorapatite in aortic valves and in other parts of the human bodies, associated with the formation of bones. (C) 2013 Elsevier Ltd. All rights reserved.
  • Degenerative aortic stenosis has become a common and dangerous disease in recent decades. This disease leads to the mineralization of aortic valves, their gradual thickening and loss of functionality. We studied the detailed assessment of the proportion and composition of inorganic and organic components in the ossified aortic valve, using a set of analytical methods applied in science: polarized light microscopy, scanning electron microscopy, X-ray fluorescence, X-ray diffraction, gas chromatography/mass spectrometry and liquid chromatography-tandem mass spectrometry. The sample valves showed the occurrence of phosphorus and calcium in the form of phosphate and calcium carbonate, hydroxyapatite, fluorapatite and hydroxy-fluorapatite, with varying content of inorganic components from 65 to 90 wt%, and with phased development of degenerative disability. The outer layers of the plaque contained an organic component with peptide bonds, fatty acids, proteins and cholesterol. The results show a correlation between the formation of fluorapatite in aortic valves and in other parts of the human bodies, associated with the formation of bones. (C) 2013 Elsevier Ltd. All rights reserved. (en)
Title
  • The structure and material composition of ossified aortic valves identified using a set of scientific methods
  • The structure and material composition of ossified aortic valves identified using a set of scientific methods (en)
skos:prefLabel
  • The structure and material composition of ossified aortic valves identified using a set of scientific methods
  • The structure and material composition of ossified aortic valves identified using a set of scientific methods (en)
skos:notation
  • RIV/00216208:11140/13:10193759!RIV14-GA0-11140___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, O, P(GA205/09/1162), S
http://linked.open...iv/cisloPeriodika
  • Special Issue
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 108385
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11140/13:10193759
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Cholesterol; Proteins; Hydroxyapatite; Degenerative (calcification-sclerotic) changes; Aortic stenosis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [CBB6A85F23A4]
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  • Journal of Asian Earth Sciences
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 77
http://linked.open...iv/tvurceVysledku
  • Havelcová, Martina
  • Hynek, Radovan
  • Kučková, Štěpánka
  • Zeman, Antonín
  • Šmíd, Michal
  • Coufalová, Lucie
  • Velčovská, Martina
http://linked.open...ain/vavai/riv/wos
  • 000326996800030
issn
  • 1367-9120
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.jseaes.2013.07.001
http://localhost/t...ganizacniJednotka
  • 11140
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