About: Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility

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About: Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://fb.cuni.cz/file/5701/FB2013A0028.pdf
Description	The aim of our work is to detect and identify seminal proteins that are related to female isoimmunization. In this report, we quantified serum anti-seminal IgG antibodies. Seminal proteins were analysed by twodimensional gel electrophoresis followed by immunoblotting. To identify IgG-binding proteins of interest, a proteomic approach was selected. The dominant seminal antigens were detected within the relative molecular mass ranging from 25 to 85 kDa and the isoelectric point from 5 to 7. The detected proteins were further identified as prostate-specific antigen, prostatic acid phosphatase, zinc-α-2-glycoprotein and zinc finger protein 778. Since these proteins were recognized by IgGs produced by infertile women and not by fertile women, we presume that major seminal antigens may play an important role in the pathogenesis of female immune infertility. Our study suggests the pattern of seminal proteins for further therapeutic attempts in the diagnosis of female immune infertility. The aim of our work is to detect and identify seminal proteins that are related to female isoimmunization. In this report, we quantified serum anti-seminal IgG antibodies. Seminal proteins were analysed by twodimensional gel electrophoresis followed by immunoblotting. To identify IgG-binding proteins of interest, a proteomic approach was selected. The dominant seminal antigens were detected within the relative molecular mass ranging from 25 to 85 kDa and the isoelectric point from 5 to 7. The detected proteins were further identified as prostate-specific antigen, prostatic acid phosphatase, zinc-α-2-glycoprotein and zinc finger protein 778. Since these proteins were recognized by IgGs produced by infertile women and not by fertile women, we presume that major seminal antigens may play an important role in the pathogenesis of female immune infertility. Our study suggests the pattern of seminal proteins for further therapeutic attempts in the diagnosis of female immune infertility. (en)
Title	Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility (en)
skos:prefLabel	Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility Immunodominant Semen Proteins II: Contribution of Seminal Proteins to Female Immune Infertility (en)
skos:notation	RIV/00216208:11140/13:10159255!RIV14-MSM-11140___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(IAA600110902), S
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Ulčová-Gallová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	78907
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/13:10159255
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prostatic acid phosphatase; prostate-specific antigen; female immune infertility; IgG antibodies (en)
http://linked.open.../riv/klicoveSlovo	IgG antibodies female immune infertility prostatic acid phosphatase prostate-specific antigen
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[CE4085FCC326]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Influence of ingestion of anthropogenically contaminated soils by heavy metals on changes of biochemical and physiological parameters of rats
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Ulčová-Gallová, Zdeňka Zídková, H. Peltre, G. Brázdová, A. Poncet, P. Sénéchal, H. Vermachová, J.
http://linked.open...ain/vavai/riv/wos	000327577300004
issn	0015-5500
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11140

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