About: Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.etap.2013.09.003
Description	In this study, oxidative stress-related parameters and As retention were examined in liverand kidneys of male Wistar rats exposed to arsenic trioxide, sodium arsenite (iAsIII), sodiumarsenate (iAsV), and dimethylarsinic acid (DMAsV) at a single ip dose of 3.8 mg As/kg bw, at24 h post-exposure. In liver, lipid peroxidation increased in iAsIII-exposed rats, glutathioneperoxidase activity decreased in inorganic arsenic (iAs)-exposed rats, and catalase and thioredoxin reductase activities decreased significantly in all As-exposed groups. Both As(III) and As(V) exposure elevated GSH level with no effect on glutathione reductase activity. In kidneys, catalase activity decreased significantly in iAs-exposed, rats; GSH level, glutathione reductase and thioredoxin reductase activity decreased in DMAsV-treated, rats. The tissue As retention was higher in kidneys compared to liver and was also higher in As(III)-exposed compared to As(V)-exposed rats. The results demonstrate similar potency of inorganic As(III) and As(V) compounds to inhibit/induce antioxidant defense system, with liver being more vulnerable to acute As(III) - and As(V) -induced oxidative stress. In this study, oxidative stress-related parameters and As retention were examined in liverand kidneys of male Wistar rats exposed to arsenic trioxide, sodium arsenite (iAsIII), sodiumarsenate (iAsV), and dimethylarsinic acid (DMAsV) at a single ip dose of 3.8 mg As/kg bw, at24 h post-exposure. In liver, lipid peroxidation increased in iAsIII-exposed rats, glutathioneperoxidase activity decreased in inorganic arsenic (iAs)-exposed rats, and catalase and thioredoxin reductase activities decreased significantly in all As-exposed groups. Both As(III) and As(V) exposure elevated GSH level with no effect on glutathione reductase activity. In kidneys, catalase activity decreased significantly in iAs-exposed, rats; GSH level, glutathione reductase and thioredoxin reductase activity decreased in DMAsV-treated, rats. The tissue As retention was higher in kidneys compared to liver and was also higher in As(III)-exposed compared to As(V)-exposed rats. The results demonstrate similar potency of inorganic As(III) and As(V) compounds to inhibit/induce antioxidant defense system, with liver being more vulnerable to acute As(III) - and As(V) -induced oxidative stress. (en)
Title	Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats (en)
skos:prefLabel	Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats (en)
skos:notation	RIV/00216208:11140/13:10139601!RIV14-MSM-11140___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620819)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kotyzová, Dana Eybl, Vladislav Bludovská, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	69650
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/13:10139601
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Selenoenzymes; Oxidative stress; Dimethylarsinic acid; Arsenic trioxide; Arsenate; Arsenite (en)
http://linked.open.../riv/klicoveSlovo	Oxidative stress Arsenate Arsenic trioxide Arsenite Dimethylarsinic acid Selenoenzymes
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[B51795D818C0]
http://linked.open...i/riv/nazevZdroje	Environmental Toxicology and Pharmacology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	36
http://linked.open...iv/tvurceVysledku	Eybl, Vladislav Kotyzová, Dana Bludovská, Monika
http://linked.open...ain/vavai/riv/wos	000329530600033
http://linked.open...n/vavai/riv/zamer	Náhrada a podpora funkce některých životně důležitých orgánů
issn	1382-6689
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.etap.2013.09.003
http://localhost/t...ganizacniJednotka	11140

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