About: Assessing colorectal cancer heterogeneity: one step closer to tailored medicine

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.2478/v10136-012-0035-6
Description	Many advances in understanding colorectal cancer heterogeneity and its impact on the variability of treatment efficacy have been achieved in recent years. New methods have also been introduced in colorectal cancer diagnosis and early detection, including molecular biology techniques as well as newly developed or improved imaging techniques. We are currently aware of some aspects of colorectal cancer heterogeneity, such as alterations in the epidermal growth factor receptor signalling or the different behaviours of tumours belonging to different genetic and epigenetic subtypes. In the future, greater attention should also be focused on other signalling circuits with the goal to treat patients individually, based on the characteristics of their tumours. This so-called personalised medicine will bring more benefits to patients, without unnecessary adverse side effects. Therefore, all new information regarding colorectal cancer biology brings us one step closer to accomplishing this goal. Many advances in understanding colorectal cancer heterogeneity and its impact on the variability of treatment efficacy have been achieved in recent years. New methods have also been introduced in colorectal cancer diagnosis and early detection, including molecular biology techniques as well as newly developed or improved imaging techniques. We are currently aware of some aspects of colorectal cancer heterogeneity, such as alterations in the epidermal growth factor receptor signalling or the different behaviours of tumours belonging to different genetic and epigenetic subtypes. In the future, greater attention should also be focused on other signalling circuits with the goal to treat patients individually, based on the characteristics of their tumours. This so-called personalised medicine will bring more benefits to patients, without unnecessary adverse side effects. Therefore, all new information regarding colorectal cancer biology brings us one step closer to accomplishing this goal. (en)
Title	Assessing colorectal cancer heterogeneity: one step closer to tailored medicine Assessing colorectal cancer heterogeneity: one step closer to tailored medicine (en)
skos:prefLabel	Assessing colorectal cancer heterogeneity: one step closer to tailored medicine Assessing colorectal cancer heterogeneity: one step closer to tailored medicine (en)
skos:notation	RIV/00216208:11140/13:10139078!RIV14-MZ0-11140___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0076), P(NT12025), P(NT13326), S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Liška, Václav Třeška, Vladislav Pitule, Pavel Čedíková, Miroslava Králíčková, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	62223
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/13:10139078
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stool DNA; circulating tumour cells; EGFR pathway; CpG island methylator phenotype; microsatellite instability; chromosomal instability; colorectal cancer (en)
http://linked.open.../riv/klicoveSlovo	CpG island methylator phenotype EGFR pathway chromosomal instability stool DNA microsatellite instability colorectal cancer circulating tumour cells
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E8A6A4B5379B]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedical Centre of the Faculty of Medicine in Pilsen Improvement of resecability of the malignant processes using the more accurate methods for measuring parametres of the remnant liver parenchyma – computer asisted diagnostic and software modeling Molecular-biological and histopathological characteristics of tumor infiltrating lymphocytes as instrument of prediction of risk of early colorectal cancer recurrence
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Liška, Václav Třeška, Vladislav Králíčková, Milena Pitule, Pavel Čedíková, Miroslava
http://linked.open...ain/vavai/riv/wos	000315854000001
issn	1214-021X
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.2478/v10136-012-0035-6
http://localhost/t...ganizacniJednotka	11140

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