About: Searching for mechanisms that matter in early septic acute kidney injury: an experimental study

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://ccforum.com/content/pdf/cc10517.pdf
Description	In almost half of all sepsis patients, acute kidney injury (AKI) develops. However, the pathobiologic differences between sepsis patients with and without AKI are only poorly understood. We used a unique opportunity to examine dynamic inflammatory, renal hemodynamic, and microvascular changes in two clinically relevant large-animal models of sepsis. Aim was to assess variability in renal responses to sepsis and to identify both hemodynamic and nonhemodynamic mechanisms discriminating individuals with AKI from those in whom AKI did not develop. Observed variability in susceptibility to septic AKI in our models replicates that of human disease. Early abnormal host response accompanied by subsequent uncoupling between systemic and renal vascular resistance appear to be major determinants in the early phase of porcine septic AKI. Nonuniform and modelrelated renal hemodynamic responses unpredictable from systemic changes should be taken into consideration when evaluating interventions in septic AKI. In almost half of all sepsis patients, acute kidney injury (AKI) develops. However, the pathobiologic differences between sepsis patients with and without AKI are only poorly understood. We used a unique opportunity to examine dynamic inflammatory, renal hemodynamic, and microvascular changes in two clinically relevant large-animal models of sepsis. Aim was to assess variability in renal responses to sepsis and to identify both hemodynamic and nonhemodynamic mechanisms discriminating individuals with AKI from those in whom AKI did not develop. Observed variability in susceptibility to septic AKI in our models replicates that of human disease. Early abnormal host response accompanied by subsequent uncoupling between systemic and renal vascular resistance appear to be major determinants in the early phase of porcine septic AKI. Nonuniform and modelrelated renal hemodynamic responses unpredictable from systemic changes should be taken into consideration when evaluating interventions in septic AKI. (en)
Title	Searching for mechanisms that matter in early septic acute kidney injury: an experimental study Searching for mechanisms that matter in early septic acute kidney injury: an experimental study (en)
skos:prefLabel	Searching for mechanisms that matter in early septic acute kidney injury: an experimental study Searching for mechanisms that matter in early septic acute kidney injury: an experimental study (en)
skos:notation	RIV/00216208:11140/11:10103438!RIV12-MSM-11140___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620819)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Raděj, Jaroslav Matějovič, Martin Beneš, Jan Novák, Ivan Chvojka, Jiří Kroužecký, Aleš Sýkora, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	228473
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/11:10103438
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	animal experiment; acute kidney injury; sepsis (en)
http://linked.open.../riv/klicoveSlovo	animal experiment sepsis acute kidney injury
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C06E67007841]
http://linked.open...i/riv/nazevZdroje	Critical Care [online]
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Chvojka, Jiří Kroužecký, Aleš Matějovič, Martin Novák, Ivan Raděj, Jaroslav Sýkora, Roman Beneš, Jan
http://linked.open...n/vavai/riv/zamer	Náhrada a podpora funkce některých životně důležitých orgánů
issn	1466-609X
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/cc10517
http://localhost/t...ganizacniJednotka	11140

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