About: Anticonvulsant and behavioral effects of muscimol in immature rats

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.brainres.2014.07.038
Description	Potentiation of GABAergic inhibition is a mechanism of action of many antiepileptic drugs. The potential use of an agonist of GABA-A receptors, muscimol, as an antiepileptic drug was studied in immature rats by assessing anticonvulsant activity and side effects on motor activities. Anticonvulsant action was tested in two models of seizures (pentetrazol-induced convulsions and cortical epileptic afterdischarges). Off target effect on motor performance was assessed in a battery of tests and in the open field in three age groups (12-, 18- and 25-day-old rats). Muscimol was administered in doses from 0.1 to 1 mg/kg i.p. Only the 1 mg/kg dose exhibited marked anticonvulsant effect against pentetrazol-induced convulsions in 12- and 18-day-old rats, proconvulsant effect was observed in the second model in 18- and 25-day-old rats as prolongation of afterdischarges. Even the 0.5 mg/kg dose suppressed spontaneous locomotion and heavily compromised motor performance. The effect on motor activity was marked in the youngest group and decreased with age. Due to the low anticonvulsant potency and serious side effects, systemic administration of a competitive agonist of GABA(A) receptors in immature animals is not a promising strategy for new anticonvulsants. Potentiation of GABAergic inhibition is a mechanism of action of many antiepileptic drugs. The potential use of an agonist of GABA-A receptors, muscimol, as an antiepileptic drug was studied in immature rats by assessing anticonvulsant activity and side effects on motor activities. Anticonvulsant action was tested in two models of seizures (pentetrazol-induced convulsions and cortical epileptic afterdischarges). Off target effect on motor performance was assessed in a battery of tests and in the open field in three age groups (12-, 18- and 25-day-old rats). Muscimol was administered in doses from 0.1 to 1 mg/kg i.p. Only the 1 mg/kg dose exhibited marked anticonvulsant effect against pentetrazol-induced convulsions in 12- and 18-day-old rats, proconvulsant effect was observed in the second model in 18- and 25-day-old rats as prolongation of afterdischarges. Even the 0.5 mg/kg dose suppressed spontaneous locomotion and heavily compromised motor performance. The effect on motor activity was marked in the youngest group and decreased with age. Due to the low anticonvulsant potency and serious side effects, systemic administration of a competitive agonist of GABA(A) receptors in immature animals is not a promising strategy for new anticonvulsants. (en)
Title	Anticonvulsant and behavioral effects of muscimol in immature rats Anticonvulsant and behavioral effects of muscimol in immature rats (en)
skos:prefLabel	Anticonvulsant and behavioral effects of muscimol in immature rats Anticonvulsant and behavioral effects of muscimol in immature rats (en)
skos:notation	RIV/00216208:11130/14:10293074!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP304/10/1274), S
http://linked.open...iv/cisloPeriodika	neuveden
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Tichá, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	3402
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/14:10293074
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rat; Muscimol; Ontogeny; Motor activities; Cortical afterdischarges; Pentetrazol-induced seizures (en)
http://linked.open.../riv/klicoveSlovo	Muscimol Rat Ontogeny Cortical afterdischarges Motor activities Pentetrazol-induced seizures
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[D0EC49379724]
http://linked.open...i/riv/nazevZdroje	Brain Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Drugs influencing GABA-B receptors in pediatric medicine
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	1582
http://linked.open...iv/tvurceVysledku	Mareš, Pavel Tichá, Kateřina Mikulecka, Anna
http://linked.open...ain/vavai/riv/wos	000343357100022
issn	0006-8993
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.brainres.2014.07.038
http://localhost/t...ganizacniJednotka	11130

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