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| Description
| - Objective: We investigated the association between APOE epsilon 4 status and spatial navigation in patients with amnestic mild cognitive impairment (aMCI) and assessed the role of hippocampal volume in this association. Method: Participants were 74 patients with clinically confirmed aMCI (33 APOE epsilon 4 noncarriers, 26 heterozygous, and 15 homozygous epsilon 4 carriers). Body-centered (egocentric) and world-centered (allocentric) spatial navigation in a computerized human analogue of the Morris Water Maze was assessed. Brain MRI with subsequent automated hippocampal volumetry was included. Results: Groups were similar in neuropsychological profile. Controlling for age, sex, education, and free memory recall, the APOE epsilon 4 carriers performed more poorly on all spatial navigation subtasks (ps < .05). APOE epsilon 4 homozygotes performed worse than heterozygotes (p = .021). Right hippocampal volume accounted for the differences in allocentric and delayed subtasks (ps > .05), but not in the egocentric subtask (p < .001). Conclusions: Using an easy-to-use, computer-based tool to assess spatial navigation, we found spatial navigation deficits to worsen in a dose-dependent manner as a function of APOE epsilon 4 status. This was at least partially due to differences in right hippocampal volume.
- Objective: We investigated the association between APOE epsilon 4 status and spatial navigation in patients with amnestic mild cognitive impairment (aMCI) and assessed the role of hippocampal volume in this association. Method: Participants were 74 patients with clinically confirmed aMCI (33 APOE epsilon 4 noncarriers, 26 heterozygous, and 15 homozygous epsilon 4 carriers). Body-centered (egocentric) and world-centered (allocentric) spatial navigation in a computerized human analogue of the Morris Water Maze was assessed. Brain MRI with subsequent automated hippocampal volumetry was included. Results: Groups were similar in neuropsychological profile. Controlling for age, sex, education, and free memory recall, the APOE epsilon 4 carriers performed more poorly on all spatial navigation subtasks (ps < .05). APOE epsilon 4 homozygotes performed worse than heterozygotes (p = .021). Right hippocampal volume accounted for the differences in allocentric and delayed subtasks (ps > .05), but not in the egocentric subtask (p < .001). Conclusions: Using an easy-to-use, computer-based tool to assess spatial navigation, we found spatial navigation deficits to worsen in a dose-dependent manner as a function of APOE epsilon 4 status. This was at least partially due to differences in right hippocampal volume. (en)
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| Title
| - APOE and Spatial Navigation in Amnestic MCI: Results From a Computer-Based Test
- APOE and Spatial Navigation in Amnestic MCI: Results From a Computer-Based Test (en)
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| skos:prefLabel
| - APOE and Spatial Navigation in Amnestic MCI: Results From a Computer-Based Test
- APOE and Spatial Navigation in Amnestic MCI: Results From a Computer-Based Test (en)
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| skos:notation
| - RIV/00216208:11130/14:10293020!RIV15-MSM-11130___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - I, P(ED1.100/02/0123), P(GA309/09/0286), P(GA309/09/1053), S, Z(AV0Z50110509)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11130/14:10293020
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - neuropsychology; Hidden Goal Task; hippocampus; apolipoprotein E; mild cognitive impairment (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hort, Jakub
- Laczó, Jan
- Vyhnálek, Martin
- Vlček, Kamil
- Gažová, Ivana
- Nedelská, Zuzana
- Andel, Ross
- Mokrišová, Ivana
- Matoska, Václav
- Sheardova, Katerina
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
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| http://localhost/t...ganizacniJednotka
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