About: Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats     Goto   Sponge   NotDistinct   Permalink

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Description
  • Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database. Published 2014 Wiley Periodicals, Inc.**
  • Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database. Published 2014 Wiley Periodicals, Inc.** (en)
Title
  • Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
  • Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats (en)
skos:prefLabel
  • Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
  • Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats (en)
skos:notation
  • RIV/00216208:11130/14:10292977!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 50784
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11130/14:10292977
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • forensic; paternal lineage; RM Y-STRs; haplotypes; Y-STRs; Y-chromosome (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [97099CD55B42]
http://linked.open...i/riv/nazevZdroje
  • Human Mutation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 35
http://linked.open...iv/tvurceVysledku
  • …
  • Comas, David
  • Capal, Tomas
  • Haas, Cordula
  • Aboukhalid, Rachid
  • Achakzai, Niaz M.
  • Anjos, Maria J.
  • Ayub, Qasim
  • Balazic, Joze
  • Ballantyne, Jack
  • Ballantyne, Kaye N.
  • Ballard, David J.
  • Berger, Burkhard
  • Bobillo, Cecilia
  • Bouabdellah, Mehdi
  • Burri, Helen
  • Caratti, Stefano
  • Cardenas, Jorge
  • Cartault, Francois
  • Carvalho, Elizeu F.
  • Carvalho, Monica
  • Cheng, Baowen
  • Coble, Michael D.
  • Corach, Daniel
  • D'Amato, Maria E.
  • Davison, Sean
  • De Ungria, Maria Corazon A.
  • Decorte, Ronny
  • Dobosz, Tadeusz
  • Dupuy, Berit M.
  • Elmrghni, Samir
  • Gliwinski, Mateusz
  • Gomes, Sara C.
  • Grol, Laurens
  • Hanson, Erin
  • Henke, Juergen
  • Henke, Lotte
  • Herrera-Rodriguez, Fabiola
  • Hill, Carolyn R.
  • Holmlund, Gunilla
  • Honda, Katsuya
  • Immel, Uta-Dorothee
  • Inokuchi, Shota
  • Jobling, Mark A.
  • Kaddura, Mahmoud
  • Kim, Jong S.
  • Kim, Soon H.
  • Kim, Wook
  • King, Turi E.
  • Klausriegler, Eva
  • Kling, Daniel
  • Kovacevic, Lejla
  • Kovatsi, Leda
  • Krajewski, Pawel
  • Kravchenko, Sergey
  • Larmuseau, Maarten H. D.
  • Ralf, Arwin
  • de Knijff, Peter
http://linked.open...ain/vavai/riv/wos
  • 000339431600016
issn
  • 1059-7794
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/humu.22599
http://localhost/t...ganizacniJednotka
  • 11130
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