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Description
| - Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database. Published 2014 Wiley Periodicals, Inc.**
- Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database. Published 2014 Wiley Periodicals, Inc.** (en)
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Title
| - Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
- Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats (en)
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skos:prefLabel
| - Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
- Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats (en)
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skos:notation
| - RIV/00216208:11130/14:10292977!RIV15-MSM-11130___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11130/14:10292977
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - forensic; paternal lineage; RM Y-STRs; haplotypes; Y-STRs; Y-chromosome (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - …
- Comas, David
- Capal, Tomas
- Haas, Cordula
- Aboukhalid, Rachid
- Achakzai, Niaz M.
- Anjos, Maria J.
- Ayub, Qasim
- Balazic, Joze
- Ballantyne, Jack
- Ballantyne, Kaye N.
- Ballard, David J.
- Berger, Burkhard
- Bobillo, Cecilia
- Bouabdellah, Mehdi
- Burri, Helen
- Caratti, Stefano
- Cardenas, Jorge
- Cartault, Francois
- Carvalho, Elizeu F.
- Carvalho, Monica
- Cheng, Baowen
- Coble, Michael D.
- Corach, Daniel
- D'Amato, Maria E.
- Davison, Sean
- De Ungria, Maria Corazon A.
- Decorte, Ronny
- Dobosz, Tadeusz
- Dupuy, Berit M.
- Elmrghni, Samir
- Gliwinski, Mateusz
- Gomes, Sara C.
- Grol, Laurens
- Hanson, Erin
- Henke, Juergen
- Henke, Lotte
- Herrera-Rodriguez, Fabiola
- Hill, Carolyn R.
- Holmlund, Gunilla
- Honda, Katsuya
- Immel, Uta-Dorothee
- Inokuchi, Shota
- Jobling, Mark A.
- Kaddura, Mahmoud
- Kim, Jong S.
- Kim, Soon H.
- Kim, Wook
- King, Turi E.
- Klausriegler, Eva
- Kling, Daniel
- Kovacevic, Lejla
- Kovatsi, Leda
- Krajewski, Pawel
- Kravchenko, Sergey
- Larmuseau, Maarten H. D.
- Ralf, Arwin
- de Knijff, Peter
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http://linked.open...ain/vavai/riv/wos
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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