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| Description
| - Background: Severe combined immunodeficiency (SCID) is a syndrome characterized by profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most countries encourage BCG vaccination at birth, a high percentage of patients with SCID are vaccinated before their immune defect is detected. Objectives: We sought to describe the complications and risks associated with BCG vaccination in patients with SCID. Methods: An extensive standardized questionnaire evaluating complications, therapeutics, and outcomes regarding BCG vaccination in patients given a diagnosis of SCID was widely distributed. Summary statistics and association analysis was performed. Results: Data on 349 BCG-vaccinated patients with SCID from 28 centers in 17 countries were analyzed. Fifty-one percent of the patients had BCG-associated complications, 34% disseminated and 17% localized (a 33,000- and 400-fold increase, respectively, over the general population). Patients receiving early vaccination ({= 3 1 month) showed an increased prevalence of complications (P = 5.006) and death caused by BCG-associated complications (P < .0001). The odds of experiencing complications among patients with T-cell numbers of 250/mu L or less at diagnosis was 2.1 times higher (95% CI, 1.4-3.4 times higher; P = .001) than among those with T-cell numbers of greater than 250/mL. BCG-associated complications were reported in 2 of 78 patients who received antimycobacterial therapy while asymptomatic, and no deaths caused by BCG-associated complications occurred in this group. In contrast, 46 BCG-associated deaths were reported among 160 patients treated with antimycobacterial therapy for a symptomatic BCG infection (P < .0001). Conclusions: BCG vaccine has a very high rate of complications in patients with SCID, which increase morbidity and mortality rates.
- Background: Severe combined immunodeficiency (SCID) is a syndrome characterized by profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most countries encourage BCG vaccination at birth, a high percentage of patients with SCID are vaccinated before their immune defect is detected. Objectives: We sought to describe the complications and risks associated with BCG vaccination in patients with SCID. Methods: An extensive standardized questionnaire evaluating complications, therapeutics, and outcomes regarding BCG vaccination in patients given a diagnosis of SCID was widely distributed. Summary statistics and association analysis was performed. Results: Data on 349 BCG-vaccinated patients with SCID from 28 centers in 17 countries were analyzed. Fifty-one percent of the patients had BCG-associated complications, 34% disseminated and 17% localized (a 33,000- and 400-fold increase, respectively, over the general population). Patients receiving early vaccination ({= 3 1 month) showed an increased prevalence of complications (P = 5.006) and death caused by BCG-associated complications (P < .0001). The odds of experiencing complications among patients with T-cell numbers of 250/mu L or less at diagnosis was 2.1 times higher (95% CI, 1.4-3.4 times higher; P = .001) than among those with T-cell numbers of greater than 250/mL. BCG-associated complications were reported in 2 of 78 patients who received antimycobacterial therapy while asymptomatic, and no deaths caused by BCG-associated complications occurred in this group. In contrast, 46 BCG-associated deaths were reported among 160 patients treated with antimycobacterial therapy for a symptomatic BCG infection (P < .0001). Conclusions: BCG vaccine has a very high rate of complications in patients with SCID, which increase morbidity and mortality rates. (en)
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| Title
| - BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies
- BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies (en)
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| skos:prefLabel
| - BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies
- BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies (en)
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| skos:notation
| - RIV/00216208:11130/14:10292786!RIV15-MSM-11130___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11130/14:10292786
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - immune reconstitution syndrome; hematopoietic stem cell transplant; newborn screening; mycobacteria; BCG; vaccine; severe combined immunodeficiency; Primary immunodeficiency (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Allergy and Clinical Immunology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Thon, Vojtěch
- …
- Formánková, Renata
- Slatter, Mary A.
- Szaflarska, Anna
- Al-Herz, Waleed
- Al-Tamemi, Salem
- Allwood, Zoe
- Ariga, Tadashi
- Bezrodnik, Liliana
- Carvalho, Beatriz Costa
- Cipe, Funda
- Cunha, Luciana
- Dogu, Figen
- Elfeky, Reem A.
- Enriqueta Nunez-Nunez, M.
- Espinosa-Padilla, Sara E.
- Espinosa-Rosales, Francisco
- Esteves, Isabel
- Franco, Jose L.
- Galal, Nermeen
- Gennery, Andrew
- Gomez Raccio, Andrea C.
- Grumach, Anete Sevciovic
- Hernandez-Nieto, Leticia
- Huang, Chiung-Yu
- Ikinciogullari, Aydan
- Joshi, Gyan
- Kilic, Sebnem
- Lau, Yu-Lung
- Liberatore, Diana
- Listello, Viviana
- Marciano, Beatriz E.
- Marques, Jose Goncalo
- Mazzucchelli, Juliana T. L.
- Morio, Tomohiro
- Nademi, Zohreh
- Nishikomori, Ryuta
- Ohtsuka, Yoshitoshi
- Orellana, Julio C.
- Pereira, Maria I.
- Pinto, Jorge A.
- Porras, Oscar
- Reda, Shereen M.
- Rezaei, Nima
- Roxo, Persio
- Shcherbina, Anna
- Tavares, Fabiola S.
- Torres-Lozano, Carlos
- Toshio, Heike
- Vilela, Maria M. S.
- Yamada, Masafumi
- Yildiran, Alisan
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.jaci.2014.02.028
|
| http://localhost/t...ganizacniJednotka
| |
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