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Description
  • Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.
  • Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed. (en)
Title
  • Inflammatory myopathy associated with statins: report of three cases
  • Inflammatory myopathy associated with statins: report of three cases (en)
skos:prefLabel
  • Inflammatory myopathy associated with statins: report of three cases
  • Inflammatory myopathy associated with statins: report of three cases (en)
skos:notation
  • RIV/00216208:11130/14:10289106!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 21289
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11130/14:10289106
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • statins; inflammatory myopathies; muscle biopsy; drug induced myopathy (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • JP - Japonsko
http://linked.open...ontrolniKodProRIV
  • [5E85B862526D]
http://linked.open...i/riv/nazevZdroje
  • Modern Rheumatology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 24
http://linked.open...iv/tvurceVysledku
  • Mann, Heřman
  • Vencovský, Jiří
  • Wenchich, László
  • Kuncová, Klára
  • Zámečník, Josef
  • Tomčík, Michal
  • Sedlackova, Marie
http://linked.open...ain/vavai/riv/wos
  • 000332483500027
issn
  • 1439-7595
number of pages
http://bibframe.org/vocab/doi
  • 10.3109/14397595.2013.852848
http://localhost/t...ganizacniJednotka
  • 11130
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