About: Study of fluorescence of doxorubicin in muscle tissue using highly sensitive fluorescence sensing

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.cognizure.com/abstract.aspx?p=107637266
Description	Monitoring the behaviour of biologically active compounds in the body is the key to understand their effect. Optical methods are relatively cheap non-ionizing techniques based on the specific optical properties and are an important tool for non-invasive and objective diagnosis with still better and better resolution. In this work, a characterization of fluorescence behaviour of doxorubicin in different environments (ethanol, methanol, dimethyl sulphoxide) has been established. In addition, its spatial distribution in muscle tissue was monitored using fluorescence imaging. Autofluorescence of the tissue was removed by software to limit the effect of the matrix. The novelty of this study lies in the field of sensing of doxorubicin in a tissue. The results can be base for an optic array, which could be used for sensing if the drug in vivo. Monitoring the behaviour of biologically active compounds in the body is the key to understand their effect. Optical methods are relatively cheap non-ionizing techniques based on the specific optical properties and are an important tool for non-invasive and objective diagnosis with still better and better resolution. In this work, a characterization of fluorescence behaviour of doxorubicin in different environments (ethanol, methanol, dimethyl sulphoxide) has been established. In addition, its spatial distribution in muscle tissue was monitored using fluorescence imaging. Autofluorescence of the tissue was removed by software to limit the effect of the matrix. The novelty of this study lies in the field of sensing of doxorubicin in a tissue. The results can be base for an optic array, which could be used for sensing if the drug in vivo. (en)
Title	Study of fluorescence of doxorubicin in muscle tissue using highly sensitive fluorescence sensing Study of fluorescence of doxorubicin in muscle tissue using highly sensitive fluorescence sensing (en)
skos:prefLabel	Study of fluorescence of doxorubicin in muscle tissue using highly sensitive fluorescence sensing Study of fluorescence of doxorubicin in muscle tissue using highly sensitive fluorescence sensing (en)
skos:notation	RIV/00216208:11130/14:10282664!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP301/10/0356)
http://linked.open...iv/cisloPeriodika	Neuveden
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Eckschlager, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	48266
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/14:10282664
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanotechnology; in vivo imaging; fluorescence spectroscopy; nanomedicine; fluorescence; doxorubicin (en)
http://linked.open.../riv/klicoveSlovo	fluorescence spectroscopy fluorescence nanotechnology in vivo imaging doxorubicin nanomedicine
http://linked.open...odStatuVydavatele	IN - Indická republika
http://linked.open...ontrolniKodProRIV	[71E164385A8C]
http://linked.open...i/riv/nazevZdroje	Chemical Sensors
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Eckschlager, Tomáš Kizek, René Stiborová, Marie Trnková, Libuše Vaculovičová, Markéta Blažková, Iva
issn	2231-6035
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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