About: Molecular Typing of Treponema pallidum in the Czech Republic during 2011 to 2013: Increased Prevalence of Identified Genotypes and of Isolates with Macrolide Resistance

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About: Molecular Typing of Treponema pallidum in the Czech Republic during 2011 to 2013: Increased Prevalence of Identified Genotypes and of Isolates with Macrolide Resistance Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1128/JCM.01292-14
Description	From January 2011 to December 2013, a total of 262 samples, from 188 patients suspected of having syphilis were tested for the presence of treponemal DNA by PCR amplification of five chromosomal loci, including the polA (TP0105), tmpC (TP0319), TP0136, TP0548, and 23S rRNA genes. Altogether, 146 samples from 103 patients were PCR positive for treponemal DNA. A set of 81 samples from 62 PCR-positive patients were typeable, and among them, nine different genotypes were identified. Compared to a previous study in the Czech Republic during 2004 to 2010, the number of genotypes detected among syphilis patients in a particular year increased to six in both 2012 and 2013, although they were not the same six. The proportion of macrolide-resistant clinical isolates in this 3-year study was 66.7%. From January 2011 to December 2013, a total of 262 samples, from 188 patients suspected of having syphilis were tested for the presence of treponemal DNA by PCR amplification of five chromosomal loci, including the polA (TP0105), tmpC (TP0319), TP0136, TP0548, and 23S rRNA genes. Altogether, 146 samples from 103 patients were PCR positive for treponemal DNA. A set of 81 samples from 62 PCR-positive patients were typeable, and among them, nine different genotypes were identified. Compared to a previous study in the Czech Republic during 2004 to 2010, the number of genotypes detected among syphilis patients in a particular year increased to six in both 2012 and 2013, although they were not the same six. The proportion of macrolide-resistant clinical isolates in this 3-year study was 66.7%. (en)
Title	Molecular Typing of Treponema pallidum in the Czech Republic during 2011 to 2013: Increased Prevalence of Identified Genotypes and of Isolates with Macrolide Resistance Molecular Typing of Treponema pallidum in the Czech Republic during 2011 to 2013: Increased Prevalence of Identified Genotypes and of Isolates with Macrolide Resistance (en)
skos:prefLabel	Molecular Typing of Treponema pallidum in the Czech Republic during 2011 to 2013: Increased Prevalence of Identified Genotypes and of Isolates with Macrolide Resistance Molecular Typing of Treponema pallidum in the Czech Republic during 2011 to 2013: Increased Prevalence of Identified Genotypes and of Isolates with Macrolide Resistance (en)
skos:notation	RIV/00216208:11130/14:10281724!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(GA310/07/0321), P(NT11159), V
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Hercogová, Jana Vaňousová, Daniela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	30312
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/14:10281724
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	china; strains; united-states; san-francisco; point mutation; subsp pallidum; primary syphilis; clinical isolate; azithromycin resistance; 23s ribosomal-rna (en)
http://linked.open.../riv/klicoveSlovo	23s ribosomal-rna azithromycin resistance clinical isolate primary syphilis san-francisco subsp pallidum china point mutation united-states strains
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D102ADB175D9]
http://linked.open...i/riv/nazevZdroje	Journal of Clinical Microbiology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular typing of syphilis-causing strains in the Czech Republic and detection of mutations leading to macrolide resistance Genomics of Treponema: comparative genome sequencing of pathogenic treponemes and transcriptome analysis of T. pallidum ssp. pallidum
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Hercogová, Jana Kojanová, Martina Kuklová, Ivana Šmajs, David Dastychová, Eliška Mikalová, Lenka Vaňousová, Daniela Zákoucká, Hana Strnadel, Radim Pětrošová, Helena Kreidlová, Miluše Procházka, Přemysl Grillová, Linda Krchňáková, Alena Vašků, Vladimir
http://linked.open...ain/vavai/riv/wos	000342371700024
issn	0095-1137
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1128/JCM.01292-14
http://localhost/t...ganizacniJednotka	11130

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