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| rdf:type
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| rdfs:seeAlso
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| Description
| - Background: In recent years different IRT/PAP protocols have been evaluated, but the individual performance remains unclear. To optimize the IRT/PAP strategy we compared protocols from three regional CF newborn screening centers (Heidelberg, Dresden, and Prague). Methods: We evaluated the effect of elevating the IRT-cut-off from 50 to 65 mu g/l (similar to 97.5th to similar to 99.0th percentile), the need of a failsafe protocol (FS, lRT }= 99.9th percentile) and the relative performance using either two lRT-dependent PAP-cut-offs or one PAP-cut-off. Findings: Elevation of the IRT cut-off to 65 mu g/l (similar to 99.0th percentile) increased the PPV significantly (Dresden: 0.065 vs. 0.080, p <0.0001, Prague: 0.052 vs. 0.074, p <0.0001) without reducing sensitivity. All three IRT/PAP protocols showed a trend towards a higher sensitivity with FS than without and when using one PAP-cut-off instead of two IRT-dependent PAP-cut-offs. Conclusions: For best performance we suggest an IRT/PAP protocol with an lRT-cut-off close to the 99.0th percentile, FS, and a single PAP-cut-off. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
- Background: In recent years different IRT/PAP protocols have been evaluated, but the individual performance remains unclear. To optimize the IRT/PAP strategy we compared protocols from three regional CF newborn screening centers (Heidelberg, Dresden, and Prague). Methods: We evaluated the effect of elevating the IRT-cut-off from 50 to 65 mu g/l (similar to 97.5th to similar to 99.0th percentile), the need of a failsafe protocol (FS, lRT }= 99.9th percentile) and the relative performance using either two lRT-dependent PAP-cut-offs or one PAP-cut-off. Findings: Elevation of the IRT cut-off to 65 mu g/l (similar to 99.0th percentile) increased the PPV significantly (Dresden: 0.065 vs. 0.080, p <0.0001, Prague: 0.052 vs. 0.074, p <0.0001) without reducing sensitivity. All three IRT/PAP protocols showed a trend towards a higher sensitivity with FS than without and when using one PAP-cut-off instead of two IRT-dependent PAP-cut-offs. Conclusions: For best performance we suggest an IRT/PAP protocol with an lRT-cut-off close to the 99.0th percentile, FS, and a single PAP-cut-off. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. (en)
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| Title
| - Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations
- Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations (en)
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| skos:prefLabel
| - Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations
- Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations (en)
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| skos:notation
| - RIV/00216208:11130/14:10210611!RIV15-MSM-11130___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11130/14:10210611
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Immunoreactive trypsinogen; Pancreatitis associated protein; Biochemical screening; Newborn screening; Cystic fibrosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Cystic Fibrosis
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Votava, Felix
- Macek, Milan
- Skalická, Veronika
- Balaščaková, Miroslava
- Krulišová, Veronika
- Gahr, Manfred
- Hammermann, Jutta
- Happich, Margit
- Hoffinann, Georg F.
- Kohlmueller, Dirk
- Kulozik, Andreas E.
- Lindner, Martin
- Mall, Marcus A.
- Muckenthaler, Martina
- Sommerburg, Olaf
- Stahl, Mirjam
- Stopsack, Marina
|
| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
| |
| http://bibframe.org/vocab/doi
| - 10.1016/j.jcf.2013.06.003
|
| http://localhost/t...ganizacniJednotka
| |
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