About: The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.biochi.2013.08.004
Description	Diseases of the central nervous system still remain among the most challenging pathologies known to mankind, having no or limited therapeutic possibilities and a very pessimistic prognosis. Advances in stem cell biology in the last decade have shown that stem cells might provide an inexhaustible source of neurons and glia as well as exerting a neuroprotective effect on the host tissue, thus opening new horizons for tissue engineering and regenerative medicine. Here, we discuss the progress made in the cell-based therapy of spinal cord injury. An emphasis has been placed on the application of adult mesenchymal stromal cells (MSCs). We then review the latest and most significant results from in vitro and in vivo research focusing on the regenerative/neuroprotective properties of MSCs. We also attempt to correlate the effect of MSCs with the pathological events that are taking place in the nervous tissue after SCI. Finally, we discuss the results from preclinical and clinical trials involving different routes of MSC application into patients with neurological disorders of the spinal cord. (C) 2013 Published by Elsevier Masson SAS. Diseases of the central nervous system still remain among the most challenging pathologies known to mankind, having no or limited therapeutic possibilities and a very pessimistic prognosis. Advances in stem cell biology in the last decade have shown that stem cells might provide an inexhaustible source of neurons and glia as well as exerting a neuroprotective effect on the host tissue, thus opening new horizons for tissue engineering and regenerative medicine. Here, we discuss the progress made in the cell-based therapy of spinal cord injury. An emphasis has been placed on the application of adult mesenchymal stromal cells (MSCs). We then review the latest and most significant results from in vitro and in vivo research focusing on the regenerative/neuroprotective properties of MSCs. We also attempt to correlate the effect of MSCs with the pathological events that are taking place in the nervous tissue after SCI. Finally, we discuss the results from preclinical and clinical trials involving different routes of MSC application into patients with neurological disorders of the spinal cord. (C) 2013 Published by Elsevier Masson SAS. (en)
Title	The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications (en)
skos:prefLabel	The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications (en)
skos:notation	RIV/00216208:11130/13:10209697!RIV14-GA0-11130___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0018), P(GA13-00939S), P(GAP304/10/0320), P(GAP304/11/0189), P(GBP304/12/G069)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Syková, Eva Jendelová, Pavla Forostyak, Serhiy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	103339
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/13:10209697
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Clinical trials; Cell-based therapy; Neuroprotection; Regeneration; Stem cells (en)
http://linked.open.../riv/klicoveSlovo	Cell-based therapy Clinical trials Stem cells Regeneration Neuroprotection
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[9EF99B69E39F]
http://linked.open...i/riv/nazevZdroje	Biochimie
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Léčba chronického míšního poranění pomocí kmenových buněk a enzymů v kombinaci s polymerními nosiči Development of Research Teams of IEM AS CR for the BIOCEV Project Project of excellence in the field of neuroscience The use of stem cells in the treatment of amyotrophic lateral sclerosis Utilization of autologous mesenchymal cells in the posterolateral spinal fusion in the degenerative spine diseases: preclinical and clinical trial
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	95
http://linked.open...iv/tvurceVysledku	Syková, Eva Jendelová, Pavla Forostyak, Serhiy
http://linked.open...ain/vavai/riv/wos	000327805400008
issn	0300-9084
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.biochi.2013.08.004
http://localhost/t...ganizacniJednotka	11130

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