About: Recovery from hypoxic pulmonary hypertension in rats

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.lfhk.cuni.cz/Data/files/Casopisy/2011/2011_73.pdf
Description	To characterize the time frame of changes in pulmonary arterial pressure, right ventricular hypertrophy and morphology of small pulmonary arteries male Wistar rats were exposed to isobaric hypoxia (3 weeks, F1O2 0.1) and then let to recover on air for 1 or 5 weeks. Normoxic animals (group N) served as controls. Mean pulmonary arterial pressure (PAP), ratio of the weight of the right heart ventricle to the sum of the weights of the left ventricle and septum (RV/LV+S) and percentage of double laminated pulmonary vessels ( % DL) were measured at the end of hypoxic exposure (group H), after 1 or 5 weeks of recovery (groups 1R and 5R), and in controls kept in air (group N). Three weeks in hypoxia resulted in increase in PAP, RV/LV+S and % DL. After 1 week of recovery RV/LV+S normalized, PAP decreased, while % DL did not change. After 5 weeks in air PAP returned to control values and % DL diminished significantly but did not normalize. Our results suggest that recovery depends on the degree of HPH and that knowledge of the time-frame of recovery is important for future studies in our rat model. To characterize the time frame of changes in pulmonary arterial pressure, right ventricular hypertrophy and morphology of small pulmonary arteries male Wistar rats were exposed to isobaric hypoxia (3 weeks, F1O2 0.1) and then let to recover on air for 1 or 5 weeks. Normoxic animals (group N) served as controls. Mean pulmonary arterial pressure (PAP), ratio of the weight of the right heart ventricle to the sum of the weights of the left ventricle and septum (RV/LV+S) and percentage of double laminated pulmonary vessels ( % DL) were measured at the end of hypoxic exposure (group H), after 1 or 5 weeks of recovery (groups 1R and 5R), and in controls kept in air (group N). Three weeks in hypoxia resulted in increase in PAP, RV/LV+S and % DL. After 1 week of recovery RV/LV+S normalized, PAP decreased, while % DL did not change. After 5 weeks in air PAP returned to control values and % DL diminished significantly but did not normalize. Our results suggest that recovery depends on the degree of HPH and that knowledge of the time-frame of recovery is important for future studies in our rat model. (en)
Title	Recovery from hypoxic pulmonary hypertension in rats Recovery from hypoxic pulmonary hypertension in rats (en)
skos:prefLabel	Recovery from hypoxic pulmonary hypertension in rats Recovery from hypoxic pulmonary hypertension in rats (en)
skos:notation	RIV/00216208:11130/11:7471!RIV12-GA0-11130___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1M0510), P(GA305/08/0108)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Maxová, Hana Vízek, Martin Baňasová, Alena Herget, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	225996
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/11:7471
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Hypoxic pulmonary hypertension; Recovery from chronic hypoxia; Pulmonary arterial pressure; Right ventricle hypertrophy; Pulmonary vascular remodeling; Rat (en)
http://linked.open.../riv/klicoveSlovo	Rat Hypoxic pulmonary hypertension Pulmonary arterial pressure Pulmonary vascular remodeling Recovery from chronic hypoxia Right ventricle hypertrophy
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[49AE81AEB15D]
http://linked.open...i/riv/nazevZdroje	Acta Medica
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Recovery from chonic lung hypoxia and effects of hypoxia in placenta. Pathophysiological basis for therapy. Centre for cardiovascular research
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Maxová, Hana Vízek, Martin Povýšilová, Viera Baňasová, Alena Herget, Jan
issn	1211-4286
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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