About: Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/21910722
Description	Hyper-immunoglobulin (Ig) E syndrome (HIES) is a primary immunodeficiency associated with mutations in STAT3 resulting in impaired development of T helper type 17 (Th17) lymphocytes. HIES patients with a reduced frequency of Th17 cells present with infections caused by Staphylococcus aureus and/or Candida strains. The same spectrum of pathogens is present in patients with chronic granulomatous disease (CGD). We analysed the characteristics of the Th17 compartment in HIES and CGD. HIES patients showed very low numbers of Th17 cells. By contrast, the frequency of Th17 cells and production of Th17-derived cytokines was significantly higher among CGD patients when compared to both control samples and HIES. Naive CD4(+) cells in CGD patients had a normal capacity to differentiate into IL-17-producing cells and the numbers of Th17 cells in the CGD patients normalized following successful bone marrow transplantation. Our findings complement recent data on the importance of Th17 cells for elimination of infections with C. albicans and S. aureus. Hyper-immunoglobulin (Ig) E syndrome (HIES) is a primary immunodeficiency associated with mutations in STAT3 resulting in impaired development of T helper type 17 (Th17) lymphocytes. HIES patients with a reduced frequency of Th17 cells present with infections caused by Staphylococcus aureus and/or Candida strains. The same spectrum of pathogens is present in patients with chronic granulomatous disease (CGD). We analysed the characteristics of the Th17 compartment in HIES and CGD. HIES patients showed very low numbers of Th17 cells. By contrast, the frequency of Th17 cells and production of Th17-derived cytokines was significantly higher among CGD patients when compared to both control samples and HIES. Naive CD4(+) cells in CGD patients had a normal capacity to differentiate into IL-17-producing cells and the numbers of Th17 cells in the CGD patients normalized following successful bone marrow transplantation. Our findings complement recent data on the importance of Th17 cells for elimination of infections with C. albicans and S. aureus. (en)
Title	Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease (en)
skos:prefLabel	Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease (en)
skos:notation	RIV/00216208:11130/11:7091!RIV12-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS10489), Z(MSM0021620812)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Sedláček, Petr Špíšek, Radek Šedivá, Anna Poloučková, Andrea Horváth, Rudolf Lašťovička, Jan Rožková, Daniela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	198676
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/11:7091
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Th17 lymphocytes; hyper-IgE; chronic granulomatous disease; candida infections; hyper-ige syndrome; t(h)17 cells; dendritic cells; interleukin-17; responses; pathway; card9; il-23; il-17; differentiation (en)
http://linked.open.../riv/klicoveSlovo	Th17 lymphocytes candida infections card9 chronic granulomatous disease hyper-IgE hyper-ige syndrome il-17 il-23 interleukin-17 pathway responses t(h)17 cells dendritic cells differentiation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[06A8A937DC95]
http://linked.open...i/riv/nazevZdroje	Clinical and Experimental Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional characteristics of circulating dendritic cells in patients with X-linked agammaglobulinemia
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	166
http://linked.open...iv/tvurceVysledku	Poloučková, Andrea Sedláček, Petr Šedivá, Anna Špíšek, Radek Horváth, Rudolf Lašťovička, Jan Rožková, Daniela
http://linked.open...ain/vavai/riv/wos	000294913700003
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby
issn	0009-9104
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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