About: The diffusion parameters of the extracellular space are altered in focal cortical dysplasias

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The diffusion parameters of the extracellular space are altered in focal cortical dysplasias Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/21620932
Description	Most hypotheses concerning the mechanisms underlying seizure activity in focal cortical dysplasia (FCD) are based on alterations in synaptic transmission and glial dysfunction. However, neurons may also communicate by extrasynaptic transmission, which was recently found to affect epileptiform activity under experimental conditions and which is mediated by the diffusion of neuroactive substances in the extracellular space (ECS). The ECS diffusion parameters were therefore determined using the real-time iontophoretic method in human neocortical tissue samples obtained from surgically treated epileptic patients. The obtained values of the extracellular space volume fraction and tortuosity were then correlated with the histologicaly assessed type of cortical malformation (FCD type I or II). While the extracellular volume remained unchanged (FCD l) or larger (FCD II) than in normal/control tissue, tortuosity was significantly increased in both types of dysplasia, indicating the presence of additional diffusion barriers and compromised diffusion, which might be another factor contributing to the epileptogenicity of FCD. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Most hypotheses concerning the mechanisms underlying seizure activity in focal cortical dysplasia (FCD) are based on alterations in synaptic transmission and glial dysfunction. However, neurons may also communicate by extrasynaptic transmission, which was recently found to affect epileptiform activity under experimental conditions and which is mediated by the diffusion of neuroactive substances in the extracellular space (ECS). The ECS diffusion parameters were therefore determined using the real-time iontophoretic method in human neocortical tissue samples obtained from surgically treated epileptic patients. The obtained values of the extracellular space volume fraction and tortuosity were then correlated with the histologicaly assessed type of cortical malformation (FCD type I or II). While the extracellular volume remained unchanged (FCD l) or larger (FCD II) than in normal/control tissue, tortuosity was significantly increased in both types of dysplasia, indicating the presence of additional diffusion barriers and compromised diffusion, which might be another factor contributing to the epileptogenicity of FCD. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (en)
Title	The diffusion parameters of the extracellular space are altered in focal cortical dysplasias The diffusion parameters of the extracellular space are altered in focal cortical dysplasias (en)
skos:prefLabel	The diffusion parameters of the extracellular space are altered in focal cortical dysplasias The diffusion parameters of the extracellular space are altered in focal cortical dysplasias (en)
skos:notation	RIV/00216208:11130/11:7038!RIV12-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS9915), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Syková, Eva Vargová, Lýdia Zámečník, Josef Cicanič, Michal Kuncová, Klára Homola, Aleš Kršek, Pavel Marusič, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	194617
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/11:7038
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Epilepsy; Focal cortical dysplasia; Diffusion; Extracellular space volume; Tortuosity; temporal neocortex; volume fraction; brain; transmission; mechanisms; tortuosity; ischemia; epilepsy; channels; tissue (en)
http://linked.open.../riv/klicoveSlovo	ischemia channels Epilepsy Extracellular space volume Focal cortical dysplasia Tortuosity temporal neocortex volume fraction Diffusion epilepsy mechanisms transmission brain tissue tortuosity
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[15E06E3EA33E]
http://linked.open...i/riv/nazevZdroje	Neuroscience Letters
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Properties of the extracellular space of the epileptic neocortex - significance for the pathogenesis and diagnosis of refractory epilepsy
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	499
http://linked.open...iv/tvurceVysledku	Marusič, Petr Syková, Eva Vargová, Lýdia Cicanič, Michal Homola, Aleš Kršek, Pavel Kuncová, Klára Zámečník, Josef
http://linked.open...ain/vavai/riv/wos	000292804200005
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	0304-3940
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software