About: Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis?

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aim: The aim of our study was to analyse cytokine composition of human milk and its relationship to the development of eosinophilic colitis (EC). Methods: Cytokines were measured by ELISA method in breast milk of 20 mothers of infants who developed EC and 20 controls. Results: We found significantly higher concentrations of interferon-gamma (IFN-gamma) (Th1 cytokine) in breast milk received by EC infants compared to controls (p = 0.0004). In contrary, IL-18 (Th1-inducing cytokine) was significantly higher in breast milk received by healthy infants comparing to EC infants (p = 0.001). Regulatory cytokine transforming growth factor beta1 (TGF-beta1) showed higher concentrations in breast milk received by healthy infants, although the difference from EC group was not significant (p = 0.072). Conclusion: The results of our study showed that infants with EC were receiving breast milk with a possibly risky cytokine pattern indicating cytokine imbalance, impaired immunoregulation and the early Th1 shift. Aim: The aim of our study was to analyse cytokine composition of human milk and its relationship to the development of eosinophilic colitis (EC). Methods: Cytokines were measured by ELISA method in breast milk of 20 mothers of infants who developed EC and 20 controls. Results: We found significantly higher concentrations of interferon-gamma (IFN-gamma) (Th1 cytokine) in breast milk received by EC infants compared to controls (p = 0.0004). In contrary, IL-18 (Th1-inducing cytokine) was significantly higher in breast milk received by healthy infants comparing to EC infants (p = 0.001). Regulatory cytokine transforming growth factor beta1 (TGF-beta1) showed higher concentrations in breast milk received by healthy infants, although the difference from EC group was not significant (p = 0.072). Conclusion: The results of our study showed that infants with EC were receiving breast milk with a possibly risky cytokine pattern indicating cytokine imbalance, impaired immunoregulation and the early Th1 shift. (en)
Title	Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis? Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis? (en)
skos:prefLabel	Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis? Is there any relationship between cytokine spectrum of breast milk and occurence of eosinophilic colitis? (en)
skos:notation	RIV/00216208:11130/10:6341!RIV11-MZ0-11130___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NR8310)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šťavíková, Vendula Durilová, Marianna Štechová, Kateřina Ulmannová, Tereza Nevoral, Jiří Petruželková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	264983
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/10:6341
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	breast milk; cytokine; eosinophilic colitis (en)
http://linked.open.../riv/klicoveSlovo	breast milk eosinophilic colitis cytokine
http://linked.open...odStatuVydavatele	NO - Norské království
http://linked.open...ontrolniKodProRIV	[E166DB261A10]
http://linked.open...i/riv/nazevZdroje	Acta Paediatrica
http://linked.open...in/vavai/riv/obor	FG
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Intestinal microflora in infants at risk of an earlier development of allergic diseases.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	99
http://linked.open...iv/tvurceVysledku	Durilová, Marianna Nevoral, Jiří Štechová, Kateřina Petruželková, Lenka Ulmannová, Tereza Šťavíková, Vendula
http://linked.open...ain/vavai/riv/wos	000282641600013
issn	0803-5253
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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