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Description
| - Objective Blood pressure enhancement induced by continuous light exposure represents an attractive but rarely investigated model of experimental hypertension. Design and methods The aim of this study was to show whether the combination of continuous light (24 h/day) exposure and chronic N-G-nitro-L-arginine-methyl ester (L-NAME) treatment induces remodelling of the left ventricle and whether captopril or melatonin can modify these potential alterations. Six groups of 3-month-old Wistar rats (nine per group) were treated for 6 weeks: control (untreated), L-NAME (40 mg/kg per day), exposed to continuous light, L-NAME treated and exposed to continuous light (L24), L24 rats treated with either captopril 100 mg/kg per day, or melatonin (10 mg/kg/24 h).
- Objective Blood pressure enhancement induced by continuous light exposure represents an attractive but rarely investigated model of experimental hypertension. Design and methods The aim of this study was to show whether the combination of continuous light (24 h/day) exposure and chronic N-G-nitro-L-arginine-methyl ester (L-NAME) treatment induces remodelling of the left ventricle and whether captopril or melatonin can modify these potential alterations. Six groups of 3-month-old Wistar rats (nine per group) were treated for 6 weeks: control (untreated), L-NAME (40 mg/kg per day), exposed to continuous light, L-NAME treated and exposed to continuous light (L24), L24 rats treated with either captopril 100 mg/kg per day, or melatonin (10 mg/kg/24 h). (en)
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Title
| - Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril
- Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril (en)
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skos:prefLabel
| - Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril
- Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril (en)
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skos:notation
| - RIV/00216208:11130/10:6327!RIV11-MSM-11130___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11130/10:6327
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - captopril; cardiac hypertrophy; continuous light and L-NAME-induced hypertension; fibrosis; melatonin; spontaneously hypertensive-rats; blood-pressure; vascular reactivity; n-acetylcysteine; heart-disease; hypertrophy; pinealectomy; simvastatin; regression; exposure (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Pelouch, Václav
- Celec, P.
- Simko, F.
- Paulis, L.
- Adamcova, M.
- Bednarova, K.
- Krajcirovicova, K.
- Palffy, R.
- Pechanova, O.
- Vrankova, S.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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