About: Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril

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About: Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objective Blood pressure enhancement induced by continuous light exposure represents an attractive but rarely investigated model of experimental hypertension. Design and methods The aim of this study was to show whether the combination of continuous light (24 h/day) exposure and chronic N-G-nitro-L-arginine-methyl ester (L-NAME) treatment induces remodelling of the left ventricle and whether captopril or melatonin can modify these potential alterations. Six groups of 3-month-old Wistar rats (nine per group) were treated for 6 weeks: control (untreated), L-NAME (40 mg/kg per day), exposed to continuous light, L-NAME treated and exposed to continuous light (L24), L24 rats treated with either captopril 100 mg/kg per day, or melatonin (10 mg/kg/24 h). Objective Blood pressure enhancement induced by continuous light exposure represents an attractive but rarely investigated model of experimental hypertension. Design and methods The aim of this study was to show whether the combination of continuous light (24 h/day) exposure and chronic N-G-nitro-L-arginine-methyl ester (L-NAME) treatment induces remodelling of the left ventricle and whether captopril or melatonin can modify these potential alterations. Six groups of 3-month-old Wistar rats (nine per group) were treated for 6 weeks: control (untreated), L-NAME (40 mg/kg per day), exposed to continuous light, L-NAME treated and exposed to continuous light (L24), L24 rats treated with either captopril 100 mg/kg per day, or melatonin (10 mg/kg/24 h). (en)
Title	Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril (en)
skos:prefLabel	Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril (en)
skos:notation	RIV/00216208:11130/10:6327!RIV11-MSM-11130___
http://linked.open...avai/riv/aktivita	I V Z
http://linked.open...avai/riv/aktivity	I, V, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pelouch, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	251984
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/10:6327
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	captopril; cardiac hypertrophy; continuous light and L-NAME-induced hypertension; fibrosis; melatonin; spontaneously hypertensive-rats; blood-pressure; vascular reactivity; n-acetylcysteine; heart-disease; hypertrophy; pinealectomy; simvastatin; regression; exposure (en)
http://linked.open.../riv/klicoveSlovo	captopril heart-disease pinealectomy cardiac hypertrophy melatonin hypertrophy exposure regression simvastatin blood-pressure fibrosis continuous light and L-NAME-induced hypertension n-acetylcysteine spontaneously hypertensive-rats vascular reactivity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4F9765253088]
http://linked.open...i/riv/nazevZdroje	Journal of Hypertension
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Pelouch, Václav Celec, P. Simko, F. Paulis, L. Adamcova, M. Bednarova, K. Krajcirovicova, K. Palffy, R. Pechanova, O. Vrankova, S.
http://linked.open...ain/vavai/riv/wos	000282665800003
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0263-6352
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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