About: Calretinin immunoreactivity in focal cortical dysplasias and in non-malformed epileptic cortex

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About: Calretinin immunoreactivity in focal cortical dysplasias and in non-malformed epileptic cortex Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Focal cortical dysplasias (FCDs) represent a prominent cause of pharmacologically intractable epilepsy. In FCD, the decrease of parvalbumin immunoreactive (PV+) inhibitory interneurons has been repeatedly documented. Here, we wanted to show whether another interneuronal population, the calretinin immunoreactive (CR+) neurons, exhibits any change in human FCD. We also investigated samples of morphologically normal temporal neocortex resected together with sclerotic hippocampus (nHSTN), where decrease of PV+ interneurons was previously documented as well Brain tissue from 24 patients surgically treated for pharmacoresistant epilepsy was examined. Calretinin immunoreactivity was qualitatively evaluated and the density of CR+ neuronal profiles was quantified. Focal cortical dysplasias (FCDs) represent a prominent cause of pharmacologically intractable epilepsy. In FCD, the decrease of parvalbumin immunoreactive (PV+) inhibitory interneurons has been repeatedly documented. Here, we wanted to show whether another interneuronal population, the calretinin immunoreactive (CR+) neurons, exhibits any change in human FCD. We also investigated samples of morphologically normal temporal neocortex resected together with sclerotic hippocampus (nHSTN), where decrease of PV+ interneurons was previously documented as well Brain tissue from 24 patients surgically treated for pharmacoresistant epilepsy was examined. Calretinin immunoreactivity was qualitatively evaluated and the density of CR+ neuronal profiles was quantified. (en)
Title	Calretinin immunoreactivity in focal cortical dysplasias and in non-malformed epileptic cortex Calretinin immunoreactivity in focal cortical dysplasias and in non-malformed epileptic cortex (en)
skos:prefLabel	Calretinin immunoreactivity in focal cortical dysplasias and in non-malformed epileptic cortex Calretinin immunoreactivity in focal cortical dysplasias and in non-malformed epileptic cortex (en)
skos:notation	RIV/00216208:11130/10:6051!RIV11-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8843), P(NS9915), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Zámečník, Josef Kršek, Pavel Barinka, Filip Marusič, Petr Druga, Rastislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	249531
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/10:6051
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Epilepsy; Cortical dysplasia; Calretinin; Inhibitory interneurons; calcium-binding proteins; local-circuit neurons; human temporal cortex; cajal-retzius cells; prefrontal cortex; alzheimers-disease; calbindin d-28k; synaptic connections; human neocortex; parvalbumin (en)
http://linked.open.../riv/klicoveSlovo	parvalbumin calcium-binding proteins Calretinin Epilepsy alzheimers-disease Cortical dysplasia Inhibitory interneurons cajal-retzius cells calbindin d-28k human neocortex human temporal cortex local-circuit neurons synaptic connections prefrontal cortex
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[C1B4F4153176]
http://linked.open...i/riv/nazevZdroje	Epilepsy Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Properties of the extracellular space of the epileptic neocortex - significance for the pathogenesis and diagnosis of refractory epilepsy Refractory focal epilepsy with normal MRI finding: Analysis of etiopathogenesis and evaluation of individual preoperative diagnostic techniques
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	88
http://linked.open...iv/tvurceVysledku	Marusič, Petr Kršek, Pavel Zámečník, Josef Druga, Rastislav Barinka, Filip
http://linked.open...ain/vavai/riv/wos	000274058700007
http://linked.open...n/vavai/riv/zamer	Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	0920-1211
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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