About: Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Distinction between grade II ependymomas and anaplastic ependymomas based on histopathological examination solely is problematic. Therefore, we performed systematic review (SR) and meta-analysis (MA) of data published on immunohistochemical prognostic markers (IPM) in intracranial ependymomas (IE) in order to establish an evidence-based perspective on their clinical value. 30 studies reporting results on IPM in IE were identified. Due to a pronounced inter-study heterogeneity, only 14 publications fulfilled the criteria for inclusion into SR. From the total of 67 immunohistochemical markers, 18 were found to correlate with prognosis. However, due to inadequate data publishing, MA could be performed only with data on proliferation marker MIB-1 (Ki-67) from 5 publications, including 337 patients: The pooled hazard ratio for overall survival was 3.16 (95% confidence interval = 1.96 – 5.09; p < 0.001) implicating that patients with tumors with higher expression of MIB-1 had a significantly worse outcome. Distinction between grade II ependymomas and anaplastic ependymomas based on histopathological examination solely is problematic. Therefore, we performed systematic review (SR) and meta-analysis (MA) of data published on immunohistochemical prognostic markers (IPM) in intracranial ependymomas (IE) in order to establish an evidence-based perspective on their clinical value. 30 studies reporting results on IPM in IE were identified. Due to a pronounced inter-study heterogeneity, only 14 publications fulfilled the criteria for inclusion into SR. From the total of 67 immunohistochemical markers, 18 were found to correlate with prognosis. However, due to inadequate data publishing, MA could be performed only with data on proliferation marker MIB-1 (Ki-67) from 5 publications, including 337 patients: The pooled hazard ratio for overall survival was 3.16 (95% confidence interval = 1.96 – 5.09; p < 0.001) implicating that patients with tumors with higher expression of MIB-1 had a significantly worse outcome. (en)
Title	Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis (en)
skos:prefLabel	Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis (en)
skos:notation	RIV/00216208:11130/09:5715!RIV10-MZ0-11130___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620812), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Janda, Aleš Zámečník, Josef Kuncová, Klára Kasal, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	318556
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:5715
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ependymoma; Immunohistochemistry; Ki-67; Meta-analysis; MIB-1; prognosis; ki-67 immunolabeling index; central-nervous-system; epithelial differentiation; cell-proliferation; labeling index; expression; survival; childhood; tumors; children (en)
http://linked.open.../riv/klicoveSlovo	cell-proliferation Ki-67 central-nervous-system children expression survival tumors Meta-analysis childhood prognosis Immunohistochemistry Ependymoma MIB-1 epithelial differentiation ki-67 immunolabeling index labeling index
http://linked.open...odStatuVydavatele	HU - Maďarsko
http://linked.open...ontrolniKodProRIV	[4967C3882D9C]
http://linked.open...i/riv/nazevZdroje	Pathology & Oncology Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Janda, Aleš Kuncová, Klára Zámečník, Josef Kasal, Pavel
http://linked.open...ain/vavai/riv/wos	000273283100009
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	1219-4956
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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