About: Metallothionein - a promising tool for cancer diagnostics

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The latest research outcomes indicate that metallothionein (MT) levels in blood and serum from cancer patients can provide information about type or clinical stage of the disease, or response to therapy. MT plays a key role in transport of essential heavy metals, detoxification of toxic metals and protection of cells against oxidation stress. Serum MT levels of cancer patients are three times higher than control patients. The elevated MT levels in cancer cells are probably related to their proliferation and protection against apoptosis. Automated electrochemical detection of MT allows its serial analysis in a very small volume with excellent sensitivity, reliability and reproducibility and therefore it can be considered as a new tool for cancer diagnosis. The latest research outcomes indicate that metallothionein (MT) levels in blood and serum from cancer patients can provide information about type or clinical stage of the disease, or response to therapy. MT plays a key role in transport of essential heavy metals, detoxification of toxic metals and protection of cells against oxidation stress. Serum MT levels of cancer patients are three times higher than control patients. The elevated MT levels in cancer cells are probably related to their proliferation and protection against apoptosis. Automated electrochemical detection of MT allows its serial analysis in a very small volume with excellent sensitivity, reliability and reproducibility and therefore it can be considered as a new tool for cancer diagnosis. (en)
Title	Metallothionein - a promising tool for cancer diagnostics Metallothionein - a promising tool for cancer diagnostics (en)
skos:prefLabel	Metallothionein - a promising tool for cancer diagnostics Metallothionein - a promising tool for cancer diagnostics (en)
skos:notation	RIV/00216208:11130/09:5473!RIV10-MSM-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA401990701), Z(MSM0021620813)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Eckschlager, Tomáš Hraběta, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	325614
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:5473
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cancer; tumour; metallothionein; marker; blood serum; factor-kappa-b; metal-compounds; trace-elements; zinc; activation; expression; protein; cells; carcinogenesis; inhibition (en)
http://linked.open.../riv/klicoveSlovo	blood serum tumour activation cancer expression inhibition protein zinc marker cells metallothionein factor-kappa-b metal-compounds carcinogenesis trace-elements
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[F51AC94A4BAD]
http://linked.open...i/riv/nazevZdroje	Bratislavské Lekárske Listy
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	110
http://linked.open...iv/tvurceVysledku	Adam, V. Eckschlager, Tomáš Hraběta, Jan Kizek, R. Fabrik, I. Krizkova, S.
http://linked.open...ain/vavai/riv/wos	000264159400006
http://linked.open...n/vavai/riv/zamer	The Molecular Basis of Childhood Malignancies and Therapeutic Applications
issn	0006-9248
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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