About: Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome

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About: Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Focal cortical dysplasia (FCD) is recognized as the major cause of focal intractable epilepsy in childhood. Various factors influencing postsurgical seizure outcome in pediatric patients with FCD have been reported. Objective: To analyze different variables in relation to seizure outcome in order to identify prognostic factors for selection of pediatric patients with FCD for epilepsy surgery. Methods: A cohort of 149 patients with histologically confirmed mild malformations of cortical development or FCD with at least 2 years of postoperative follow-up was retrospectively studied; 113 subjects had at least 5 years of postoperative follow-up. Twenty-eight clinical, EEG, MRI, neuropsychological, surgical, and histopathologic parameters were evaluated. Results: The only significant predictor of surgical success was completeness of surgical resection, defined as complete removal of the structural MRI lesion (if present) and the cortical region exhibiting prominent ictal and interictal abnormal Background: Focal cortical dysplasia (FCD) is recognized as the major cause of focal intractable epilepsy in childhood. Various factors influencing postsurgical seizure outcome in pediatric patients with FCD have been reported. Objective: To analyze different variables in relation to seizure outcome in order to identify prognostic factors for selection of pediatric patients with FCD for epilepsy surgery. Methods: A cohort of 149 patients with histologically confirmed mild malformations of cortical development or FCD with at least 2 years of postoperative follow-up was retrospectively studied; 113 subjects had at least 5 years of postoperative follow-up. Twenty-eight clinical, EEG, MRI, neuropsychological, surgical, and histopathologic parameters were evaluated. Results: The only significant predictor of surgical success was completeness of surgical resection, defined as complete removal of the structural MRI lesion (if present) and the cortical region exhibiting prominent ictal and interictal abnormal (en)
Title	Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome (en)
skos:prefLabel	Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome (en)
skos:notation	RIV/00216208:11130/09:5354!RIV10-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8843), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kršek, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	318961
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:5354
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pediatric epilepsy surgery; surgical-treatment; intractable epilepsy; intrinsic epileptogenicity; children; malformations; lesions; eeg; classification; subtypes (en)
http://linked.open.../riv/klicoveSlovo	intractable epilepsy surgical-treatment children classification malformations lesions subtypes eeg intrinsic epileptogenicity pediatric epilepsy surgery
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EDCDA7E01E2E]
http://linked.open...i/riv/nazevZdroje	Neurology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Refractory focal epilepsy with normal MRI finding: Analysis of etiopathogenesis and evaluation of individual preoperative diagnostic techniques
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	72
http://linked.open...iv/tvurceVysledku	Kršek, Pavel Vinters, HV Duchowny, M. Dean, P. Dunoyer, C. Jayakar, P. Korman, B. Maton, B. Resnick, T. Rey, G. Morrison, G. Ragheb, J. Pacheco-Jacome, E.
http://linked.open...ain/vavai/riv/wos	000262624300005
http://linked.open...n/vavai/riv/zamer	Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	0028-3878
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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