About: Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study

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About: Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is involved, and more than 50 translocation partners have been described. We retrospectively collected outcome data of 756 childrenwith 11q23- or MLL-rearranged AML from 11 collaborative groups to identify differences in outcome based on translocation partners. The event-free survival of 11q23/MLL-rearranged pediatric AML at 5 years from diagnosis was 44%, with large differences across subgroups. We identified large differences in outcome within 11q23/MLL-rearranged pediatric AML and novel subgroups based on translocation partners that independenty predict clinical outcome. Screening for these translocation partners is needed for accurate treatment stratification at diagnosis. Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is involved, and more than 50 translocation partners have been described. We retrospectively collected outcome data of 756 childrenwith 11q23- or MLL-rearranged AML from 11 collaborative groups to identify differences in outcome based on translocation partners. The event-free survival of 11q23/MLL-rearranged pediatric AML at 5 years from diagnosis was 44%, with large differences across subgroups. We identified large differences in outcome within 11q23/MLL-rearranged pediatric AML and novel subgroups based on translocation partners that independenty predict clinical outcome. Screening for these translocation partners is needed for accurate treatment stratification at diagnosis. (en)
Title	Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study (en)
skos:prefLabel	Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study (en)
skos:notation	RIV/00216208:11130/09:5339!RIV10-MSM-11130___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620813)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Starý, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	330061
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:5339
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acute lymphoblastic-leukemia; acute myeloblastic-leukemia; childrens-oncology-group; aml trials; chromosomal-abnormalities; group-b; cancer; mll; multicenter; adolescents (en)
http://linked.open.../riv/klicoveSlovo	aml trials childrens-oncology-group chromosomal-abnormalities group-b cancer adolescents multicenter mll acute lymphoblastic-leukemia acute myeloblastic-leukemia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[96E13D449797]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	34 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	114
http://linked.open...iv/tvurceVysledku	Balgobind, BV Creutzig, U. Dworzak, MN Hasle, H. Kaspers, GJL Pieters, R. Reinhardt, D. Starý, Jan Zimmermann, M. Zwaan, CM van den Heuvel-Eibrink, MM Beverloo, H. B. Zemanová, Z. Harbott, J. Alonzo, TA Auvrignon, A. Chang, M. Forestier, E. Gibson, B. Harrison, CJ Heerema, NA Leszl, A. Litvinko, N. Lo Nigro, L. Morimoto, A. Perot, C. Raimondi, SC Rubnitz, J. E Smith, FO Stasevich, I. Strehl, S. Taga, T. Tomizawa, D. Webb, D.
http://linked.open...ain/vavai/riv/wos	000269925000017
http://linked.open...n/vavai/riv/zamer	The Molecular Basis of Childhood Malignancies and Therapeutic Applications
issn	0006-4971
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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