About: Quantification of fusion transcript reveals a subgroup with distinct biological properties and predicts relapse in BCR/ABL-positive ALL: implications for residual disease monitoring

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About: Quantification of fusion transcript reveals a subgroup with distinct biological properties and predicts relapse in BCR/ABL-positive ALL: implications for residual disease monitoring Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We analysed and compared MRD levels quantified by BCR/ABL transcript detection and by the standard Ig/TCR-based method in 218 bone marrow specimens from 17 children with BCR/ABL-positive ALL. We found only a limited overall correlation of MRD levels as assessed by the two methods. We show that multilineage involvement is at least partly responsible for the discrepancy. Our data demonstrate that BCR/ABL monitoring enables better and earlier prediction of relapse compared to the standard Ig/TCR methodology. We analysed and compared MRD levels quantified by BCR/ABL transcript detection and by the standard Ig/TCR-based method in 218 bone marrow specimens from 17 children with BCR/ABL-positive ALL. We found only a limited overall correlation of MRD levels as assessed by the two methods. We show that multilineage involvement is at least partly responsible for the discrepancy. Our data demonstrate that BCR/ABL monitoring enables better and earlier prediction of relapse compared to the standard Ig/TCR methodology. (en)
Title	Quantification of fusion transcript reveals a subgroup with distinct biological properties and predicts relapse in BCR/ABL-positive ALL: implications for residual disease monitoring Quantification of fusion transcript reveals a subgroup with distinct biological properties and predicts relapse in BCR/ABL-positive ALL: implications for residual disease monitoring (en)
skos:prefLabel	Quantification of fusion transcript reveals a subgroup with distinct biological properties and predicts relapse in BCR/ABL-positive ALL: implications for residual disease monitoring Quantification of fusion transcript reveals a subgroup with distinct biological properties and predicts relapse in BCR/ABL-positive ALL: implications for residual disease monitoring (en)
skos:notation	RIV/00216208:11130/09:5331!RIV10-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS10004), Z(MSM0021620813), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Trka, Jan Mejstříková, Ester Starý, Jan Zuna, Jan Žaliová, Markéta Froňková, Eva Krejčíková, Kateřina Mužíková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	337832
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:5331
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acute lymphoblastic leukaemia; BCR/ABL; Ig/TCR; minimal residual disease; relapse; acute lymphoblastic-leukemia; time quantitative pcr; polymerase-chain-reaction; chronic myeloid-leukemia; extremely poor-prognosis; philadelphia-chromosome; gene rearrangements; molecular response; concerted action; messenger-rna (en)
http://linked.open.../riv/klicoveSlovo	BCR/ABL polymerase-chain-reaction relapse chronic myeloid-leukemia philadelphia-chromosome messenger-rna molecular response gene rearrangements acute lymphoblastic-leukemia concerted action minimal residual disease time quantitative pcr acute lymphoblastic leukaemia Ig/TCR extremely poor-prognosis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[144CC290B53F]
http://linked.open...i/riv/nazevZdroje	Leukemia
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification of new very high risk subroups of childhood leukaemia
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Froňková, Eva Mejstříková, Ester Starý, Jan Trka, Jan Zuna, Jan Žaliová, Markéta Krejčíková, Kateřina Mužíková, Kateřina
http://linked.open...ain/vavai/riv/wos	000266006100017
http://linked.open...n/vavai/riv/zamer	The Molecular Basis of Childhood Malignancies and Therapeutic Applications Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	0887-6924
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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