About: Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II

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About: Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	PURPOSE: Cortical dysplasia (FCD) is a frequent cause of epilepsy in childhood. Two major pathological variants are distinguished, FCD type I and II. The aim of the study was to characterize differences between FCD type I and II. METHODS: Forty children with refractory epilepsy and histopathologically confirmed FCD were retrospectively analyzed. FCD type I was identified in 24 and FCD type II in 16 patients. CONCLUSIONS: Clinically important differences were found in children with distinct histopathological subtypes of FCD. Due to prominent neuropsychological deficits and worse seizure outcome, treatment strategies in FCD type I are more challenging than previously reported and these children should be recognized and specifically addressed within the incoherent group of patients with malformative brain disorders. PURPOSE: Cortical dysplasia (FCD) is a frequent cause of epilepsy in childhood. Two major pathological variants are distinguished, FCD type I and II. The aim of the study was to characterize differences between FCD type I and II. METHODS: Forty children with refractory epilepsy and histopathologically confirmed FCD were retrospectively analyzed. FCD type I was identified in 24 and FCD type II in 16 patients. CONCLUSIONS: Clinically important differences were found in children with distinct histopathological subtypes of FCD. Due to prominent neuropsychological deficits and worse seizure outcome, treatment strategies in FCD type I are more challenging than previously reported and these children should be recognized and specifically addressed within the incoherent group of patients with malformative brain disorders. (en)
Title	Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II (en)
skos:prefLabel	Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II (en)
skos:notation	RIV/00216208:11130/09:4225!RIV10-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8843), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kršek, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	310477
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:4225
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Epilepsy surgery; Cortical malformation; MRI; EEG; Neuropsychology; Seizure outcome; neuronal migration disorders; pediatric epilepsy surgery; dual pathology; intractable epilepsy; clinical correlations; malformations; classification; features; subtypes; abnormalities (en)
http://linked.open.../riv/klicoveSlovo	intractable epilepsy features EEG MRI abnormalities classification malformations subtypes Epilepsy surgery clinical correlations dual pathology Neuropsychology Seizure outcome neuronal migration disorders Cortical malformation pediatric epilepsy surgery
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[16B953A9DFBD]
http://linked.open...i/riv/nazevZdroje	Epilepsia
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Refractory focal epilepsy with normal MRI finding: Analysis of etiopathogenesis and evaluation of individual preoperative diagnostic techniques
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Kršek, Pavel Bluemcke, Ingmar Hildebrandt, Michelle Holthausen, Hans Karlmeier, Anja Kolodziejczyk, Dieter Pauli, Elisabeth Pieper, Tom Winkler, Peter
http://linked.open...ain/vavai/riv/wos	000262224500012
http://linked.open...n/vavai/riv/zamer	Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	0013-9580
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	11130

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