About: Performance of the Resolute Zotarolimus-Eluting Stent in Small Vessels

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Drug eluting stents for the treatment of small vessel coronary artery disease have traditionally yielded inferior clinical outcomes compared to the use of DES in large vessels. The benefit of the second-generation Resolute zotarolimus-eluting stent (R-ZES) in small vessels was examined. Methods: Two-year clinical outcomes from five combined R-ZES studies were compared between patients with small (reference vessel diameter [RVD] <= 2.5 mm; n = 1,956) and large (RVD >2.5 mm; n = 3174) vessels. Results: Despite a higher incidence of comorbidities in the small vessel group, there was no significant difference in target lesion failure (TLF) (10.1% vs. 8.7%; P = 0.54) at 2 years. When the subgroup of patients with diabetes was examined (n = 1,553) there was no significant difference in 2-year TLF in small compared to large vessels (11.2% vs. 11.1%; P = 0.17). Similarly, within the small vessel cohort, no significant difference was seen regarding TLF at 2 years between people with and without diabetes (11.2% vs 9.6%; P = 0.28). Conclusion: When used for the treatment of small vessels, the R-ZES appears to provide acceptable clinical results at 2 years when compared to its performance in large vessels. Background: Drug eluting stents for the treatment of small vessel coronary artery disease have traditionally yielded inferior clinical outcomes compared to the use of DES in large vessels. The benefit of the second-generation Resolute zotarolimus-eluting stent (R-ZES) in small vessels was examined. Methods: Two-year clinical outcomes from five combined R-ZES studies were compared between patients with small (reference vessel diameter [RVD] <= 2.5 mm; n = 1,956) and large (RVD >2.5 mm; n = 3174) vessels. Results: Despite a higher incidence of comorbidities in the small vessel group, there was no significant difference in target lesion failure (TLF) (10.1% vs. 8.7%; P = 0.54) at 2 years. When the subgroup of patients with diabetes was examined (n = 1,553) there was no significant difference in 2-year TLF in small compared to large vessels (11.2% vs. 11.1%; P = 0.17). Similarly, within the small vessel cohort, no significant difference was seen regarding TLF at 2 years between people with and without diabetes (11.2% vs 9.6%; P = 0.28). Conclusion: When used for the treatment of small vessels, the R-ZES appears to provide acceptable clinical results at 2 years when compared to its performance in large vessels. (en)
Title	Performance of the Resolute Zotarolimus-Eluting Stent in Small Vessels Performance of the Resolute Zotarolimus-Eluting Stent in Small Vessels (en)
skos:prefLabel	Performance of the Resolute Zotarolimus-Eluting Stent in Small Vessels Performance of the Resolute Zotarolimus-Eluting Stent in Small Vessels (en)
skos:notation	RIV/00216208:11120/14:43908648!RIV15-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Widimský, P.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	36173
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/14:43908648
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	small vessel disease; diabetes; drug eluting stent; coronary artery disease (en)
http://linked.open.../riv/klicoveSlovo	small vessel disease coronary artery disease drug eluting stent diabetes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CBD72164C4D4]
http://linked.open...i/riv/nazevZdroje	Catheterization and Cardiovascular Interventions
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	84
http://linked.open...iv/tvurceVysledku	Widimský, Petr
http://linked.open...ain/vavai/riv/wos	000337970100007
issn	1522-1946
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ccd.25485
http://localhost/t...ganizacniJednotka	11120

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