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rdf:type
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Description
| - Mucosal associated invariant T (MAIT) cells are innate-like T cells comprising up to 10% of the peripheral blood T cells in humans. During ontogeny, MAIT cells can first be detected in the cord blood in low amounts, but rise steadily after birth. In this population-based study, we show that their counts continue to increase, reaching maximal levels (4.5% of CD3+ cells, 65 cells/μl) in the third and fourth decenniums. At this age, the amounts of MAIT cells exhibit the highest inter-individual variability. The values then dramatically decline; subjects 80 years old and older have on average 10 times less MAIT cells, both absolutely and as a percentage among CD3+ T cells, than subjects in fertile age. The senescence of MAIT cells is associated with decreased CD8/double negative (DN) ratio. Finally, we observed significantly higher amounts of MAIT cells in females of reproductive age than in males of the same age. Our data suggests that further studies aimed at elucidating a role of MAIT cells in human pathologies must recruit age- and gender- matched controls.
- Mucosal associated invariant T (MAIT) cells are innate-like T cells comprising up to 10% of the peripheral blood T cells in humans. During ontogeny, MAIT cells can first be detected in the cord blood in low amounts, but rise steadily after birth. In this population-based study, we show that their counts continue to increase, reaching maximal levels (4.5% of CD3+ cells, 65 cells/μl) in the third and fourth decenniums. At this age, the amounts of MAIT cells exhibit the highest inter-individual variability. The values then dramatically decline; subjects 80 years old and older have on average 10 times less MAIT cells, both absolutely and as a percentage among CD3+ T cells, than subjects in fertile age. The senescence of MAIT cells is associated with decreased CD8/double negative (DN) ratio. Finally, we observed significantly higher amounts of MAIT cells in females of reproductive age than in males of the same age. Our data suggests that further studies aimed at elucidating a role of MAIT cells in human pathologies must recruit age- and gender- matched controls. (en)
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Title
| - The decrease in number and change in phenotype of mucosal-associated invariant T cells in the elderly and differences in males and females of reproductive age
- The decrease in number and change in phenotype of mucosal-associated invariant T cells in the elderly and differences in males and females of reproductive age (en)
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skos:prefLabel
| - The decrease in number and change in phenotype of mucosal-associated invariant T cells in the elderly and differences in males and females of reproductive age
- The decrease in number and change in phenotype of mucosal-associated invariant T cells in the elderly and differences in males and females of reproductive age (en)
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skos:notation
| - RIV/00216208:11120/14:43908644!RIV15-MSM-11120___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/14:43908644
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Gender; Aging; MAIT cells (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Scandinavian Journal of Immunology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kozák, Tomáš
- Novák, Jan
- Nováková, Lucie
- Dobrovolný, Jan
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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