About: Prevention or Early Cure of Type 1 Diabetes by Intranasal Administration of Gliadin in NOD Mice     Goto   Sponge   NotDistinct   Permalink

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Description
  • Induction of long-term tolerance to beta-cell autoantigens has been investigated both in animal models and in human type 1 diabetes (T1D) in order to prevent the disease. As regards external compounds, the dietary plant protein fraction has been associated with high penetrance of the disease, whereas gluten-free diets prevent T1D in animal models. Herewith we investigated whether intranasal (i.n.) administration of gliadin or gluten may arrest the diabetogenic process. I.n. administration of gliadin to 4-week-old NOD mice significantly reduced the diabetes incidence. Similarly, the insulitis was lowered. Intranasal gliadin also rescued a fraction of prediabetic 13-week-old NOD mice from progressing to clinical onset of diabetes compared to OVA-treated controls. Vaccination with i.n. gliadin led to an induction of CD4(+)Foxp3(+) T cells and even more significant induction of gamma delta T cells in mucosal, but not in non-mucosal lymphoid compartments. This prevention strategy was characterized by an increased proportion of IL-10 and a decreased proportion of IL-2, IL-4 and IFN-gamma-positive CD4(+)Foxp3(+) T cells, and IFN-gamma-positive gamma delta T cells, preferentially in mucosal lymphoid organs. In conclusion, i.n. vaccination with gliadin, an environmental antigen with possible etiological influence in T1D, may represent a novel, safer strategy for prevention or even early cure of T1D.
  • Induction of long-term tolerance to beta-cell autoantigens has been investigated both in animal models and in human type 1 diabetes (T1D) in order to prevent the disease. As regards external compounds, the dietary plant protein fraction has been associated with high penetrance of the disease, whereas gluten-free diets prevent T1D in animal models. Herewith we investigated whether intranasal (i.n.) administration of gliadin or gluten may arrest the diabetogenic process. I.n. administration of gliadin to 4-week-old NOD mice significantly reduced the diabetes incidence. Similarly, the insulitis was lowered. Intranasal gliadin also rescued a fraction of prediabetic 13-week-old NOD mice from progressing to clinical onset of diabetes compared to OVA-treated controls. Vaccination with i.n. gliadin led to an induction of CD4(+)Foxp3(+) T cells and even more significant induction of gamma delta T cells in mucosal, but not in non-mucosal lymphoid compartments. This prevention strategy was characterized by an increased proportion of IL-10 and a decreased proportion of IL-2, IL-4 and IFN-gamma-positive CD4(+)Foxp3(+) T cells, and IFN-gamma-positive gamma delta T cells, preferentially in mucosal lymphoid organs. In conclusion, i.n. vaccination with gliadin, an environmental antigen with possible etiological influence in T1D, may represent a novel, safer strategy for prevention or even early cure of T1D. (en)
Title
  • Prevention or Early Cure of Type 1 Diabetes by Intranasal Administration of Gliadin in NOD Mice
  • Prevention or Early Cure of Type 1 Diabetes by Intranasal Administration of Gliadin in NOD Mice (en)
skos:prefLabel
  • Prevention or Early Cure of Type 1 Diabetes by Intranasal Administration of Gliadin in NOD Mice
  • Prevention or Early Cure of Type 1 Diabetes by Intranasal Administration of Gliadin in NOD Mice (en)
skos:notation
  • RIV/00216208:11120/14:43908572!RIV15-MSM-11120___
http://linked.open...avai/riv/aktivita
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  • I, V
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 39203
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  • RIV/00216208:11120/14:43908572
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  • insulin; bb rat; wheat gluten; oral tolerance; immune-responses; autoimmune-diseases; celiac-disease; cd4(+)cd25(+) t-cells; glutamic-acid decarboxylase; gluten-free diet (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [C7C66EB5A597]
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  • PLoS One
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http://linked.open...v/svazekPeriodika
  • 9
http://linked.open...iv/tvurceVysledku
  • Fundová, Petra
http://linked.open...ain/vavai/riv/wos
  • 000336736200090
issn
  • 1932-6203
number of pages
http://bibframe.org/vocab/doi
  • 10.1371/journal.pone.0094530
http://localhost/t...ganizacniJednotka
  • 11120
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