About: Association Between Antiretroviral Exposure and Renal Impairment Among HIV-Positive Persons With Normal Baseline Renal Function: the D:A:D Study(a)

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About: Association Between Antiretroviral Exposure and Renal Impairment Among HIV-Positive Persons With Normal Baseline Renal Function: the D:A:D Study(a) Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DAD study participants with an estimated glomerular filtration rate after 1 January 2004 were followed until they had a confirmed eGFR of < 70 mL/min (the threshold below which we hypothesized that renal interventions may begin to occur) or < 60 mL/min (a value indicative of moderately severe chronic kidney disease or until the last eGFR measurement during follow-up. An eGFR was considered confirmed if it was detected at 2 consecutive measurements >= 3 months apart. Predictors and eGFR-related ARV discontinuations were identified using Poisson regression. Conclusions. Tenofovir, ritonavir-boosted atazanavir, and ritonavir-boosted lopinavir use were independent predictors of chronic renal impairment in HIV-positive persons without preexisting renal impairment. Increased tenofovir discontinuation rates with decreasing eGFR may have prevented further deteriorations. After discontinuation, the ARV-associated incidence rates decreased. DAD study participants with an estimated glomerular filtration rate after 1 January 2004 were followed until they had a confirmed eGFR of < 70 mL/min (the threshold below which we hypothesized that renal interventions may begin to occur) or < 60 mL/min (a value indicative of moderately severe chronic kidney disease or until the last eGFR measurement during follow-up. An eGFR was considered confirmed if it was detected at 2 consecutive measurements >= 3 months apart. Predictors and eGFR-related ARV discontinuations were identified using Poisson regression. Conclusions. Tenofovir, ritonavir-boosted atazanavir, and ritonavir-boosted lopinavir use were independent predictors of chronic renal impairment in HIV-positive persons without preexisting renal impairment. Increased tenofovir discontinuation rates with decreasing eGFR may have prevented further deteriorations. After discontinuation, the ARV-associated incidence rates decreased. (en)
Title	Association Between Antiretroviral Exposure and Renal Impairment Among HIV-Positive Persons With Normal Baseline Renal Function: the D:A:D Study(a) Association Between Antiretroviral Exposure and Renal Impairment Among HIV-Positive Persons With Normal Baseline Renal Function: the D:A:D Study(a) (en)
skos:prefLabel	Association Between Antiretroviral Exposure and Renal Impairment Among HIV-Positive Persons With Normal Baseline Renal Function: the D:A:D Study(a) Association Between Antiretroviral Exposure and Renal Impairment Among HIV-Positive Persons With Normal Baseline Renal Function: the D:A:D Study(a) (en)
skos:notation	RIV/00216208:11120/13:43908294!RIV14-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Machala, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	62337
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/13:43908294
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nephrotoxicity; chronic kidney disease; lopinavir; atazanavir; tenofovir; ART; eGFR; HIV (en)
http://linked.open.../riv/klicoveSlovo	atazanavir chronic kidney disease tenofovir HIV lopinavir eGFR ART nephrotoxicity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B842A50FBA92]
http://linked.open...i/riv/nazevZdroje	Journal of Infectious Diseases
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	728 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	207
http://linked.open...iv/tvurceVysledku	Machala, Ladislav
http://linked.open...ain/vavai/riv/wos	000317434600003
issn	0022-1899
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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