About: 6. Pharmacological management of cognitive deficit in schizophrenia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cognitive deficit represents the core impairment in schizophrenia that fundamentally affects course and functional outcome of illness. Thus far, generally held views claim that conventional antipsychotics are less effective in cognitive remediation; furthermore, cognition may be worsened by the adjuvant anticholinergic medication used to alleviate from side effects. However, several earlier and recent reports indicated that a low dosage of typical antipsychotics may possess procognitive properties. Unequivocally positive effects of virtually all second-generation antipsychotics in remediation of a cognitive deficit have been shown in both individual studies and meta-analyses. The key role in cognition is played by dopamine activity in the prefrontal cortex. Dopamine action is mediated through D1 receptors, as evidenced by the improvement of cognitive performance following administration of D1 agonists. Stimulation of dopamine neurotransmission is rate-limited: low doses enhance cognition whereas higher doses may cause cognitive impairments. Dopamine activity can be also modulated indirectly, via serotonin receptor system, either with 5-HT1a agonists or 5-HT2 antagonists. Cognitive deficit represents the core impairment in schizophrenia that fundamentally affects course and functional outcome of illness. Thus far, generally held views claim that conventional antipsychotics are less effective in cognitive remediation; furthermore, cognition may be worsened by the adjuvant anticholinergic medication used to alleviate from side effects. However, several earlier and recent reports indicated that a low dosage of typical antipsychotics may possess procognitive properties. Unequivocally positive effects of virtually all second-generation antipsychotics in remediation of a cognitive deficit have been shown in both individual studies and meta-analyses. The key role in cognition is played by dopamine activity in the prefrontal cortex. Dopamine action is mediated through D1 receptors, as evidenced by the improvement of cognitive performance following administration of D1 agonists. Stimulation of dopamine neurotransmission is rate-limited: low doses enhance cognition whereas higher doses may cause cognitive impairments. Dopamine activity can be also modulated indirectly, via serotonin receptor system, either with 5-HT1a agonists or 5-HT2 antagonists. (en)
Title	6. Pharmacological management of cognitive deficit in schizophrenia 6. Pharmacological management of cognitive deficit in schizophrenia (en)
skos:prefLabel	6. Pharmacological management of cognitive deficit in schizophrenia 6. Pharmacological management of cognitive deficit in schizophrenia (en)
skos:notation	RIV/00216208:11120/13:43908191!RIV14-MSM-11120___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1M0517)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Mohr, Pavel
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	119930
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/13:43908191
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glutamate; norepinephrine; dopamine; antipsychotics; cognition; schizophrenia (en)
http://linked.open.../riv/klicoveSlovo	glutamate cognition schizophrenia antipsychotics dopamine norepinephrine
http://linked.open...ontrolniKodProRIV	[39F250B7BE67]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...i/riv/nazevZdroje	Cognitive Deficit in Mental and Neurological Disorders
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	469 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application)
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Mohr, Pavel
number of pages	13 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Nova Science Publishers
https://schema.org/isbn	978-1-60741-957-0
http://localhost/t...ganizacniJednotka	11120

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