About: The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels     Goto   Sponge   NotDistinct   Permalink

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  • Objective: To assess the expression of the novel adipokine Fatty Acid Binding Protein-4 (FABP4) in synovial tissues, serum and the synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationships among FABP4, disease activity and metabolic status. Methods: FABP4 levels were measured in the serum and synovial fluid of 40 patients with RA and 40 control patients with OA. The disease activity score (DAS28), C-reactive protein (CRP) levels and serum lipids were assessed in patients with RA. Immunohistochemical analysis and confocal microscopy were used to study the expression and cell-specific distribution of FABP4 in synovial tissues. Results: The age, sex and body mass index (BMI) adjusted levels of FABP4 were significantly higher in the serum (p = 0.001) and synovial fluid (p = 0.005) of patients with RA when compared to OA patients. FABP4 levels were higher in females than in males and correlated positively with body mass index (BMI) in patients with RA. Independent of confounders, FABP4 levels correlated with total cholesterol and LDL cholesterol in patients with RA, but not in OA patients. FABP4 levels were not affected by disease activity. Furthermore, the increased expression of FABP4 that was otherwise restricted to synovial fibroblasts, macrophages and B-cells was noted in RA patients at levels higher than that observed in OA patients. Conclusions: The observed elevation of FABP4 levels in RA patients and the positive correlation of the adipokine to cholesterol suggest(that FABP4 may represent a potential link between RA and the increased risk of atherosclerotic changes.
  • Objective: To assess the expression of the novel adipokine Fatty Acid Binding Protein-4 (FABP4) in synovial tissues, serum and the synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationships among FABP4, disease activity and metabolic status. Methods: FABP4 levels were measured in the serum and synovial fluid of 40 patients with RA and 40 control patients with OA. The disease activity score (DAS28), C-reactive protein (CRP) levels and serum lipids were assessed in patients with RA. Immunohistochemical analysis and confocal microscopy were used to study the expression and cell-specific distribution of FABP4 in synovial tissues. Results: The age, sex and body mass index (BMI) adjusted levels of FABP4 were significantly higher in the serum (p = 0.001) and synovial fluid (p = 0.005) of patients with RA when compared to OA patients. FABP4 levels were higher in females than in males and correlated positively with body mass index (BMI) in patients with RA. Independent of confounders, FABP4 levels correlated with total cholesterol and LDL cholesterol in patients with RA, but not in OA patients. FABP4 levels were not affected by disease activity. Furthermore, the increased expression of FABP4 that was otherwise restricted to synovial fibroblasts, macrophages and B-cells was noted in RA patients at levels higher than that observed in OA patients. Conclusions: The observed elevation of FABP4 levels in RA patients and the positive correlation of the adipokine to cholesterol suggest(that FABP4 may represent a potential link between RA and the increased risk of atherosclerotic changes. (en)
Title
  • The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels
  • The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels (en)
skos:prefLabel
  • The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels
  • The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels (en)
skos:notation
  • RIV/00216208:11120/13:43907676!RIV14-MSM-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S, V
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
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  • 84790
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/13:43907676
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Lipid profile; Inflammation; FABP4; Rheumatoid arthritis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [52D8CC7884BD]
http://linked.open...i/riv/nazevZdroje
  • Cytokine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 64
http://linked.open...iv/tvurceVysledku
  • Vernerová, Zdeňka
http://linked.open...ain/vavai/riv/wos
  • 000325442700063
issn
  • 1043-4666
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.cyto.2013.05.001
http://localhost/t...ganizacniJednotka
  • 11120
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