About: Topical use of tranexamic acid in cardiac surgery - A review and meta-analysis of four randomized controlled trials

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About: Topical use of tranexamic acid in cardiac surgery - A review and meta-analysis of four randomized controlled trials Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The article deals with the issue of topical use of tranexamic acid in cardiac surgery. Four randomized, double-blind trials comparing tranexamic acid vs. placebo were identified in the available literature (371 patients in total). In all of these studies the topical application of tranexamic acid significantly reduced postoperative blood loss, whereas a significant reduction of transfusion requirements was only described in one of these studies. A meta-analytic approach confirmed a significant reduction in blood loss (in 24 h) by 321.6 ml on average (95% confidence interval -530.3 ml, -112.9 ml; p=0.003). Another trial was performed to examine a possible augmentation of systemic administration of tranexamic acid by the additional topical application. Despite an evident tendency toward lower blood loss in the group treated also topically, the differences between groups in this study did not reach statistical significance. There is an apparent need for further controlled trials with larger groups of patients. The article deals with the issue of topical use of tranexamic acid in cardiac surgery. Four randomized, double-blind trials comparing tranexamic acid vs. placebo were identified in the available literature (371 patients in total). In all of these studies the topical application of tranexamic acid significantly reduced postoperative blood loss, whereas a significant reduction of transfusion requirements was only described in one of these studies. A meta-analytic approach confirmed a significant reduction in blood loss (in 24 h) by 321.6 ml on average (95% confidence interval -530.3 ml, -112.9 ml; p=0.003). Another trial was performed to examine a possible augmentation of systemic administration of tranexamic acid by the additional topical application. Despite an evident tendency toward lower blood loss in the group treated also topically, the differences between groups in this study did not reach statistical significance. There is an apparent need for further controlled trials with larger groups of patients. (en)
Title	Topical use of tranexamic acid in cardiac surgery - A review and meta-analysis of four randomized controlled trials Topical use of tranexamic acid in cardiac surgery - A review and meta-analysis of four randomized controlled trials (en)
skos:prefLabel	Topical use of tranexamic acid in cardiac surgery - A review and meta-analysis of four randomized controlled trials Topical use of tranexamic acid in cardiac surgery - A review and meta-analysis of four randomized controlled trials (en)
skos:notation	RIV/00216208:11120/13:43907358!RIV14-MSM-11120___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vaněk, Tomáš Straka, Z.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	111275
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/13:43907358
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Meta-analysis; Tranexamic acid; Topical application; Fibrinolytic inhibitors; Fibrinolysis; Cardiac surgery (en)
http://linked.open.../riv/klicoveSlovo	Fibrinolysis Fibrinolytic inhibitors Tranexamic acid Topical application Meta-analysis Cardiac surgery
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B60A6888946F]
http://linked.open...i/riv/nazevZdroje	Cor et Vasa
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Vaněk, Tomáš Straka, Zbyněk
issn	0010-8650
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.crvasa.2012.10.002
http://localhost/t...ganizacniJednotka	11120

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