About: Synapsin II Is Involved in the Molecular Pathway of Lithium Treatment in Bipolar Disorder

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About: Synapsin II Is Involved in the Molecular Pathway of Lithium Treatment in Bipolar Disorder Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bipolar disorder (BD) is a debilitating psychiatric condition with a prevalence of 1-2% in the general population that is characterized by severe episodic shifts in mood ranging from depressive to manic episodes. One of the most common treatments is lithium (Li), with successful response in 30-60% of patients. Synapsin II (SYN2) is a neuronal phosphoprotein that we have previously identified as a possible candidate gene for the etiology of BD and/or response to Li treatment in a genome-wide linkage study focusing on BD patients characterized for excellent response to Li prophylaxis. In the present study we investigated the role of this gene in BD, particularly as it pertains to Li treatment. We investigated the effect of lithium treatment on the expression of SYN2 in lymphoblastoid cell lines from patients characterized as excellent Li-responders, non-responders, as well as non-psychiatric controls. Finally, we sought to determine if Li has a cell-type-specific effect on gene expression in neuronal-derived cell lines. In both in vitro models, we found SYN2 to be modulated by the presence of Li. By focusing on Li-responsive BD we have identified a potential mechanism for Li response in some patients. Bipolar disorder (BD) is a debilitating psychiatric condition with a prevalence of 1-2% in the general population that is characterized by severe episodic shifts in mood ranging from depressive to manic episodes. One of the most common treatments is lithium (Li), with successful response in 30-60% of patients. Synapsin II (SYN2) is a neuronal phosphoprotein that we have previously identified as a possible candidate gene for the etiology of BD and/or response to Li treatment in a genome-wide linkage study focusing on BD patients characterized for excellent response to Li prophylaxis. In the present study we investigated the role of this gene in BD, particularly as it pertains to Li treatment. We investigated the effect of lithium treatment on the expression of SYN2 in lymphoblastoid cell lines from patients characterized as excellent Li-responders, non-responders, as well as non-psychiatric controls. Finally, we sought to determine if Li has a cell-type-specific effect on gene expression in neuronal-derived cell lines. In both in vitro models, we found SYN2 to be modulated by the presence of Li. By focusing on Li-responsive BD we have identified a potential mechanism for Li response in some patients. (en)
Title	Synapsin II Is Involved in the Molecular Pathway of Lithium Treatment in Bipolar Disorder Synapsin II Is Involved in the Molecular Pathway of Lithium Treatment in Bipolar Disorder (en)
skos:prefLabel	Synapsin II Is Involved in the Molecular Pathway of Lithium Treatment in Bipolar Disorder Synapsin II Is Involved in the Molecular Pathway of Lithium Treatment in Bipolar Disorder (en)
skos:notation	RIV/00216208:11120/12:43906850!RIV13-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Alda, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	172827
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/12:43906850
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Illness; Association; Lymphoblasts; Family; Schizophrenia; Suicide Risk; Valproic Acid; Gene-Expression; Nonneuronal Cells; Prophylactic Treatment (en)
http://linked.open.../riv/klicoveSlovo	Schizophrenia Illness Gene-Expression Association Family Lymphoblasts Nonneuronal Cells Prophylactic Treatment Suicide Risk Valproic Acid
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[24DA47C97086]
http://linked.open...i/riv/nazevZdroje	PLoS One
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Alda, Martin
http://linked.open...ain/vavai/riv/wos	000302916800043
issn	1932-6203
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0032680
http://localhost/t...ganizacniJednotka	11120

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