About: Tau protein and anti-tau antibodies in patients with multiple sclerosis

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About: Tau protein and anti-tau antibodies in patients with multiple sclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.csnn.eu/ceska-slovenska-neurologie-clanek/tau-protein-a-anti-tau-protilatky-u-pacientu-s-roztrousenou-sklerozou-38120?confirm_rules=1
Description	Background: Neuronal damage in multiple sclerosis (MS) may be associated with the release of cytoskeletal tau protein. This antigen interacts with dysregulated immune system and this results in anti-tau antibody synthesis. Tau-protein concentrations and anti-tau antibody levels in cerebrospinal fluid (CSF) and in serum may correlate. Methods: Total tau protein and anti- -tau antibodies measured using ELISA methods were studied in 31 patients (14 MS patients and 17 neurological controls). We calculated three ratios: the CSF tau concentration to a) the CSF anti-tau antibody level, b) the serum anti-tau antibody concentration and c) the level of intrathecal anti-tau antibodies. Results: We did not find any significant correlation between the tau protein concentrations and anti-tau antibody levels (serum, CSF or intrathecal) in the MS group or in the controls. There was no difference in the CSF tau concentrations or any of the calculated ratios between MS patients and controls. Conclusions: The release of tau protein into CSF and anti-tau humoral response are independent processes in MS and do not differentiate the MS patients from other neurological patients. Background: Neuronal damage in multiple sclerosis (MS) may be associated with the release of cytoskeletal tau protein. This antigen interacts with dysregulated immune system and this results in anti-tau antibody synthesis. Tau-protein concentrations and anti-tau antibody levels in cerebrospinal fluid (CSF) and in serum may correlate. Methods: Total tau protein and anti- -tau antibodies measured using ELISA methods were studied in 31 patients (14 MS patients and 17 neurological controls). We calculated three ratios: the CSF tau concentration to a) the CSF anti-tau antibody level, b) the serum anti-tau antibody concentration and c) the level of intrathecal anti-tau antibodies. Results: We did not find any significant correlation between the tau protein concentrations and anti-tau antibody levels (serum, CSF or intrathecal) in the MS group or in the controls. There was no difference in the CSF tau concentrations or any of the calculated ratios between MS patients and controls. Conclusions: The release of tau protein into CSF and anti-tau humoral response are independent processes in MS and do not differentiate the MS patients from other neurological patients. (en)
Title	Tau protein and anti-tau antibodies in patients with multiple sclerosis Tau protein and anti-tau antibodies in patients with multiple sclerosis (en)
skos:prefLabel	Tau protein and anti-tau antibodies in patients with multiple sclerosis Tau protein and anti-tau antibodies in patients with multiple sclerosis (en)
skos:notation	RIV/00216208:11120/12:43903694!RIV13-MZ0-11120___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS10369)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Bartoš, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	173278
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/12:43903694
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple sclerosis; cerebrospinal fluid; autoantibodies; tau protein (en)
http://linked.open.../riv/klicoveSlovo	tau protein autoantibodies multiple sclerosis cerebrospinal fluid
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[CF2014EA1A69]
http://linked.open...i/riv/nazevZdroje	Česká a slovenská neurologie a neurochirurgie
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Use of neurocytoskeletal proteins and antibodies against them for diagnosis of Alzheimer´s disease
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Bartoš, Aleš Fialová, Lenka
http://linked.open...ain/vavai/riv/wos	000305819900006
issn	1210-7859
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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