About: An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin

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About: An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We tested the relation between a single short tonic-clonic seizure elicited by flurothyl vapors and changes of learning in Morris water maze (MWM) in Wistar rats. Oxidative stress usually accompanies seizures. Large melatonin doses were applied immediately before and after seizures to test consequences on learning impairment. One hour of hypobaric hypoxia (8000 m) three days prior to the seizure served as an activator of intrinsic antioxidant systems. Learning in MWM (7 days) started 24 h after seizures. Following seizures, latencies in MWM were longer than in controls and were shortened by hypoxia and preventive melatonin application. Melatonin was also applied before hypoxia to influence free radical (FR) production and intrinsic antioxidant activation. Some behavioral characteristics were changed and preconditioning effect of hypoxia was reduced. Melatonin after seizure (150 s and 6 h) had negligible effect. Results allow us to hypothesize about the role of FR and the beneficial effect of melatonin on the behavioral consequences of seizures. We tested the relation between a single short tonic-clonic seizure elicited by flurothyl vapors and changes of learning in Morris water maze (MWM) in Wistar rats. Oxidative stress usually accompanies seizures. Large melatonin doses were applied immediately before and after seizures to test consequences on learning impairment. One hour of hypobaric hypoxia (8000 m) three days prior to the seizure served as an activator of intrinsic antioxidant systems. Learning in MWM (7 days) started 24 h after seizures. Following seizures, latencies in MWM were longer than in controls and were shortened by hypoxia and preventive melatonin application. Melatonin was also applied before hypoxia to influence free radical (FR) production and intrinsic antioxidant activation. Some behavioral characteristics were changed and preconditioning effect of hypoxia was reduced. Melatonin after seizure (150 s and 6 h) had negligible effect. Results allow us to hypothesize about the role of FR and the beneficial effect of melatonin on the behavioral consequences of seizures. (en)
Title	An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin (en)
skos:prefLabel	An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin (en)
skos:notation	RIV/00216208:11120/12:43900920!RIV13-MSM-11120___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pometlová, Marie Krýsl, David Rokyta, Richard Deykun, Kateryna Mareš, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	122008
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/12:43900920
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Oxidative stress; Rat; Water maze; Epileptic seizure; Flurothyl (en)
http://linked.open.../riv/klicoveSlovo	Epileptic seizure Flurothyl Water maze Oxidative stress Rat
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8057E2990F71]
http://linked.open...i/riv/nazevZdroje	Epilepsy & Behavior
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Krýsl, David Mareš, Jan Pometlová, Marie Rokyta, Richard Deykun, Kateryna
http://linked.open...ain/vavai/riv/wos	000301657900004
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	1525-5050
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.yebeh.2011.11.018
http://localhost/t...ganizacniJednotka	11120

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