About: Comparative Chemosensitivity of Circulating Human Prostate Cancer Cells and Primary Cancer Cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Comparative Chemosensitivity of Circulating Human Prostate Cancer Cells and Primary Cancer Cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The chemosensitivity of circulating PC-3 human prostate cancer cells, isolated from nude mice orthotopically implanted with PC-3, was compared to that of the parental PC-3 cells. PC-3 and circulating PC-3, both labeled with green fluorescent protein (GFP), were seeded in 96-well plates. The MTT assay was then performed at 24, 48, and 72 hours, comparing control cultures to cultures treated with cisplatin at 1, 2.5, 5 and 10 mu m/ml, and docetaxel at 10, 20, 25 and 50 mu m/ml at each time point. The circulating tumor cells (CTCs) exhibited a significantly increased sensitivity to both cisplatin and docetaxel when compared to PC-3 parental cells, with docetaxel having the greater efficacy. The future goal, based on these studies, is the culture of CTCs from cancer patients' peripheral blood for chemosensitivity testing, for improved individualized therapy. The chemosensitivity of circulating PC-3 human prostate cancer cells, isolated from nude mice orthotopically implanted with PC-3, was compared to that of the parental PC-3 cells. PC-3 and circulating PC-3, both labeled with green fluorescent protein (GFP), were seeded in 96-well plates. The MTT assay was then performed at 24, 48, and 72 hours, comparing control cultures to cultures treated with cisplatin at 1, 2.5, 5 and 10 mu m/ml, and docetaxel at 10, 20, 25 and 50 mu m/ml at each time point. The circulating tumor cells (CTCs) exhibited a significantly increased sensitivity to both cisplatin and docetaxel when compared to PC-3 parental cells, with docetaxel having the greater efficacy. The future goal, based on these studies, is the culture of CTCs from cancer patients' peripheral blood for chemosensitivity testing, for improved individualized therapy. (en)
Title	Comparative Chemosensitivity of Circulating Human Prostate Cancer Cells and Primary Cancer Cells Comparative Chemosensitivity of Circulating Human Prostate Cancer Cells and Primary Cancer Cells (en)
skos:prefLabel	Comparative Chemosensitivity of Circulating Human Prostate Cancer Cells and Primary Cancer Cells Comparative Chemosensitivity of Circulating Human Prostate Cancer Cells and Primary Cancer Cells (en)
skos:notation	RIV/00216208:11120/12:43895896!RIV13-MSM-11120___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	7; Spec. Iss. SI
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Bobek, Vladimír Kološtová, Katarína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	127807
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/12:43895896
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	fluorescence imaging; PC-3 prostate cancer; green fluorescent protein; metastasis; CTCs; Circulating tumor cells (en)
http://linked.open.../riv/klicoveSlovo	metastasis CTCs Circulating tumor cells fluorescence imaging PC-3 prostate cancer green fluorescent protein
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[7B1FD480C509]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Bobek, Vladimír Kološtová, Katarína
http://linked.open...ain/vavai/riv/wos	000306254300057
issn	0250-7005
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software